Home > Publications database > Mediation of the Association Between Vascular Risk Factors and Depressive Symptoms by C-Reactive Protein: Longitudinal Evidence from the UK Biobank > print

001     941224
005     20230123101919.0
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024 7 _ |a 2128/33693
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037 _ _ |a FZJ-2023-00827
100 1 _ |a Romankiewicz, Lina
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245 _ _ |a Mediation of the Association Between Vascular Risk Factors and Depressive Symptoms by C-Reactive Protein: Longitudinal Evidence from the UK Biobank
260 _ _ |c 2022
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520 _ _ |a People with vascular risk factors (VRFs) are at higher risk for depressive symptoms. Given recent findings implicating low-grade systemic inflammation in both vascular and mental health, this study examined the extent to which the VRF–depressive symptom association might be mediated by low-grade systemic inflammation. To this end, we analysed longitudinal data of 9,034 participants from the UK Biobank (mean age = 56.54 years), who took part in three consecutive assessments over the course of about 8 years. Cumulative VRF burden at baseline was defined as the presence of 5 VRFs (hypertension, obesity, hypercholesterolemia, diabetes, and smoking). Low-grade systemic inflammation was assessed using serum-derived C-reactive protein (CRP) and depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9). We performed mediation models using longitudinal data and a path analytic framework, while controlling for age, gender, racial-ethnic background, socioeconomic status, and baseline mood. VRFs at baseline showed a small association with higher depressive symptoms at follow-up (total effect = 0.014, 95% CI [0.007; 0.021]). CRP mediated this association (indirect effect = 0.003, 95% CI [0.001; 0.005]) and accounted for 20.10% of the total effect of VRF burden on depressive symptoms. Exploratory analyses taking a symptom-based approach revealed that mediating pathways pertained to specific depressive symptoms: tiredness and changes in appetite. These results suggest that the small association between VRF burden and depressive symptoms may be partly explained by the inflammation-promoting effects of VRFs, which might promote a specific symptom-profile of depression.
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700 1 _ |a Schaare, Lina
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700 1 _ |a Nestler, Steffen
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700 1 _ |a Villringer, Arno
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700 1 _ |a Blöchl, Maria
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773 _ _ |a 10.31234/osf.io/m8zv4
856 4 _ |u https://juser.fz-juelich.de/record/941224/files/preprint_romankiewicz_vrfinfdep_v1-1.pdf
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914 1 _ |y 2022
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