TY  - JOUR
AU  - Sudarev, Vsevolod V.
AU  - Dolotova, Sofya M.
AU  - Bukhalovich, Siarhei M.
AU  - Bazhenov, Sergey V.
AU  - Ryzhykau, Yury L.
AU  - Uversky, Vladimir N.
AU  - Bondarev, Nikolay A.
AU  - Osipov, Stepan D.
AU  - Mikhailov, Anatolii E.
AU  - Kuklina, Daria D.
AU  - Murugova, Tatiana N.
AU  - Manukhov, Ilya V.
AU  - Rogachev, Andrey V.
AU  - Gordeliy, Valentin I.
AU  - Gushchin, Ivan Yu.
AU  - Kuklin, Alexander I.
AU  - Vlasov, Alexey V.
TI  - Ferritin self-assembly, structure, function, and biotechnological applications
JO  - International journal of biological macromolecules
VL  - 224
SN  - 0141-8130
CY  - New York, NY [u.a.]
PB  - Elsevier
M1  - FZJ-2023-00918
SP  - 319 - 343
PY  - 2023
AB  - Ferritin is a vital protein complex responsible for storing iron in almost all living organisms. It plays a crucial role in various metabolic pathways, inflammation processes, stress response, and pathogenesis of cancer and neurodegenerative diseases. In this review we discuss the role of ferritin in diseases, cellular iron regulation, its structural features, and its role in biotechnology. We also show that molecular mechanisms of ferritin self-assembly are key for a number of biotechnological and pharmaceutical applications. The assembly pathways strongly depend on the interface context of ferritin monomers and the stability of its different intermediate oligomers. To date, several schemes of self-assembly kinetics have been proposed. Here, we compare different self-assembly mechanisms and discuss the possibility of self-assembly control by switching between deadlock intermediate states.
LB  - PUB:(DE-HGF)16
C6  - 36280176
UR  - <Go to ISI:>//WOS:000907015900001
DO  - DOI:10.1016/j.ijbiomac.2022.10.126
UR  - https://juser.fz-juelich.de/record/943312
ER  -