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@ARTICLE{Sudarev:943312,
author = {Sudarev, Vsevolod V. and Dolotova, Sofya M. and
Bukhalovich, Siarhei M. and Bazhenov, Sergey V. and
Ryzhykau, Yury L. and Uversky, Vladimir N. and Bondarev,
Nikolay A. and Osipov, Stepan D. and Mikhailov, Anatolii E.
and Kuklina, Daria D. and Murugova, Tatiana N. and Manukhov,
Ilya V. and Rogachev, Andrey V. and Gordeliy, Valentin I.
and Gushchin, Ivan Yu. and Kuklin, Alexander I. and Vlasov,
Alexey V.},
title = {{F}erritin self-assembly, structure, function, and
biotechnological applications},
journal = {International journal of biological macromolecules},
volume = {224},
issn = {0141-8130},
address = {New York, NY [u.a.]},
publisher = {Elsevier},
reportid = {FZJ-2023-00918},
pages = {319 - 343},
year = {2023},
abstract = {Ferritin is a vital protein complex responsible for storing
iron in almost all living organisms. It plays a crucial role
in various metabolic pathways, inflammation processes,
stress response, and pathogenesis of cancer and
neurodegenerative diseases. In this review we discuss the
role of ferritin in diseases, cellular iron regulation, its
structural features, and its role in biotechnology. We also
show that molecular mechanisms of ferritin self-assembly are
key for a number of biotechnological and pharmaceutical
applications. The assembly pathways strongly depend on the
interface context of ferritin monomers and the stability of
its different intermediate oligomers. To date, several
schemes of self-assembly kinetics have been proposed. Here,
we compare different self-assembly mechanisms and discuss
the possibility of self-assembly control by switching
between deadlock intermediate states.},
cin = {IBI-7},
ddc = {570},
cid = {I:(DE-Juel1)IBI-7-20200312},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
pubmed = {36280176},
UT = {WOS:000907015900001},
doi = {10.1016/j.ijbiomac.2022.10.126},
url = {https://juser.fz-juelich.de/record/943312},
}