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000943344 1001_ $$0P:(DE-HGF)0$$aLešnik, Samo$$b0
000943344 245__ $$aOpioid Receptors and Protonation-Coupled Binding of Opioid Drugs
000943344 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2021
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000943344 520__ $$aOpioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain. Pain may associate with inflamed tissue characterized by acidic pH. The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding to the opioid receptor, because opioid drugs typically have a protonated amino group that contributes to receptor binding, and the functioning of GPCRs may involve protonation change. In this review, we discuss the relationship between structure, function, and dynamics of opioid receptors from the perspective of the usefulness of computational studies to evaluate protonation-coupled opioid-receptor interactions
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000943344 7001_ $$00000-0003-1673-5178$$aBertalan, Éva$$b1
000943344 7001_ $$0P:(DE-HGF)0$$aBren, Urban$$b2
000943344 7001_ $$0P:(DE-Juel1)187548$$aBondar, Ana-Nicoleta$$b3$$eCorresponding author$$ufzj
000943344 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms222413353$$gVol. 22, no. 24, p. 13353 -$$n24$$p13353 -$$tInternational journal of molecular sciences$$v22$$x1422-0067$$y2021
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