TY  - JOUR
AU  - Lešnik, Samo
AU  - Bertalan, Éva
AU  - Bren, Urban
AU  - Bondar, Ana-Nicoleta
TI  - Opioid Receptors and Protonation-Coupled Binding of Opioid Drugs
JO  - International journal of molecular sciences
VL  - 22
IS  - 24
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - FZJ-2023-00950
SP  - 13353 -
PY  - 2021
AB  - Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of direct interest to treat pain. Pain may associate with inflamed tissue characterized by acidic pH. The potentially low pH at tissue targeted by opioid drugs in pain management could impact drug binding to the opioid receptor, because opioid drugs typically have a protonated amino group that contributes to receptor binding, and the functioning of GPCRs may involve protonation change. In this review, we discuss the relationship between structure, function, and dynamics of opioid receptors from the perspective of the usefulness of computational studies to evaluate protonation-coupled opioid-receptor interactions
LB  - PUB:(DE-HGF)16
C6  - 34948150
UR  - <Go to ISI:>//WOS:000738602000001
DO  - DOI:10.3390/ijms222413353
UR  - https://juser.fz-juelich.de/record/943344
ER  -