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@ARTICLE{Lenik:943344,
      author       = {Lešnik, Samo and Bertalan, Éva and Bren, Urban and
                      Bondar, Ana-Nicoleta},
      title        = {{O}pioid {R}eceptors and {P}rotonation-{C}oupled {B}inding
                      of {O}pioid {D}rugs},
      journal      = {International journal of molecular sciences},
      volume       = {22},
      number       = {24},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2023-00950},
      pages        = {13353 -},
      year         = {2021},
      abstract     = {Opioid receptors are G-protein-coupled receptors (GPCRs)
                      part of cell signaling paths of direct interest to treat
                      pain. Pain may associate with inflamed tissue characterized
                      by acidic pH. The potentially low pH at tissue targeted by
                      opioid drugs in pain management could impact drug binding to
                      the opioid receptor, because opioid drugs typically have a
                      protonated amino group that contributes to receptor binding,
                      and the functioning of GPCRs may involve protonation change.
                      In this review, we discuss the relationship between
                      structure, function, and dynamics of opioid receptors from
                      the perspective of the usefulness of computational studies
                      to evaluate protonation-coupled opioid-receptor
                      interactions},
      cin          = {IAS-5 / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {34948150},
      UT           = {WOS:000738602000001},
      doi          = {10.3390/ijms222413353},
      url          = {https://juser.fz-juelich.de/record/943344},
}