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000943378 1001_ $$00000-0002-8231-5895$$aMarjault, Henri-Baptiste$$b0
000943378 245__ $$aStructure-Based Screening Reveals a Ligand That Stabilizes the [2Fe-2S] Clusters of Human mitoNEET and Reduces Ovarian Cancer Cell Proliferation
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000943378 520__ $$aHuman NEET proteins play an important role in a variety of diseases, including cancer. Using the recently published X-ray structure of the human mNT-M1 complex, we screened a commercial chemical compound library and identified a new human mitoNEET (mNT) binding ligand (NTS-01). Biochemical investigations revealed that NTS-01 specifically binds to the human mNT protein and stabilizes its [2Fe-2S] clusters under oxidative conditions in vitro. Treatment of ovarian cancer cells with NTS-01 induces ovarian cancer (SKOV-3) mitochondrial fragmentation (fission) and reduces ovarian cancer cell proliferation in a 2D single-layer cell culture, as well as in a 3D-spheroids culture. The NTS-01 molecule represents therefore a new lead compound for further drug design studies attempting to develop efficient treatment against ovarian cancer.
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000943378 7001_ $$0P:(DE-HGF)0$$aYang-Sung, Sohn$$b1
000943378 7001_ $$0P:(DE-Juel1)192214$$aZuo, Ke$$b2
000943378 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b3
000943378 7001_ $$0P:(DE-HGF)0$$aMittler, Ron$$b4
000943378 7001_ $$0P:(DE-HGF)0$$aNechushtai, Rachel$$b5$$eCorresponding author
000943378 773__ $$0PERI:(DE-600)2006039-7$$a10.1021/acs.jpcb.2c05728$$gVol. 126, no. 46, p. 9559 - 9565$$n46$$p9559 - 9565$$tThe journal of physical chemistry <Washington, DC> / B$$v126$$x1520-6106$$y2022
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