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@ARTICLE{Marjault:943378,
      author       = {Marjault, Henri-Baptiste and Yang-Sung, Sohn and Zuo, Ke
                      and Carloni, Paolo and Mittler, Ron and Nechushtai, Rachel},
      title        = {{S}tructure-{B}ased {S}creening {R}eveals a {L}igand {T}hat
                      {S}tabilizes the [2{F}e-2{S}] {C}lusters of {H}uman
                      mito{NEET} and {R}educes {O}varian {C}ancer {C}ell
                      {P}roliferation},
      journal      = {The journal of physical chemistry / B},
      volume       = {126},
      number       = {46},
      issn         = {1520-6106},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2023-00977},
      pages        = {9559 - 9565},
      year         = {2022},
      abstract     = {Human NEET proteins play an important role in a variety of
                      diseases, including cancer. Using the recently published
                      X-ray structure of the human mNT-M1 complex, we screened a
                      commercial chemical compound library and identified a new
                      human mitoNEET (mNT) binding ligand (NTS-01). Biochemical
                      investigations revealed that NTS-01 specifically binds to
                      the human mNT protein and stabilizes its [2Fe-2S] clusters
                      under oxidative conditions in vitro. Treatment of ovarian
                      cancer cells with NTS-01 induces ovarian cancer (SKOV-3)
                      mitochondrial fragmentation (fission) and reduces ovarian
                      cancer cell proliferation in a 2D single-layer cell culture,
                      as well as in a 3D-spheroids culture. The NTS-01 molecule
                      represents therefore a new lead compound for further drug
                      design studies attempting to develop efficient treatment
                      against ovarian cancer.},
      cin          = {IAS-5 / INM-9},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36374279},
      UT           = {WOS:000885419200001},
      doi          = {10.1021/acs.jpcb.2c05728},
      url          = {https://juser.fz-juelich.de/record/943378},
}