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| Home > Publications database > Structure-Based Screening Reveals a Ligand That Stabilizes the [2Fe-2S] Clusters of Human mitoNEET and Reduces Ovarian Cancer Cell Proliferation > print |
| 001 | 943378 | ||
| 005 | 20240625095115.0 | ||
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| 100 | 1 | _ | |a Marjault, Henri-Baptiste |0 0000-0002-8231-5895 |b 0 |
| 245 | _ | _ | |a Structure-Based Screening Reveals a Ligand That Stabilizes the [2Fe-2S] Clusters of Human mitoNEET and Reduces Ovarian Cancer Cell Proliferation |
| 260 | _ | _ | |a Washington, DC |c 2022 |b Soc. |
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| 520 | _ | _ | |a Human NEET proteins play an important role in a variety of diseases, including cancer. Using the recently published X-ray structure of the human mNT-M1 complex, we screened a commercial chemical compound library and identified a new human mitoNEET (mNT) binding ligand (NTS-01). Biochemical investigations revealed that NTS-01 specifically binds to the human mNT protein and stabilizes its [2Fe-2S] clusters under oxidative conditions in vitro. Treatment of ovarian cancer cells with NTS-01 induces ovarian cancer (SKOV-3) mitochondrial fragmentation (fission) and reduces ovarian cancer cell proliferation in a 2D single-layer cell culture, as well as in a 3D-spheroids culture. The NTS-01 molecule represents therefore a new lead compound for further drug design studies attempting to develop efficient treatment against ovarian cancer. |
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| 700 | 1 | _ | |a Yang-Sung, Sohn |0 P:(DE-HGF)0 |b 1 |
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| 700 | 1 | _ | |a Carloni, Paolo |0 P:(DE-Juel1)145614 |b 3 |
| 700 | 1 | _ | |a Mittler, Ron |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Nechushtai, Rachel |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1021/acs.jpcb.2c05728 |g Vol. 126, no. 46, p. 9559 - 9565 |0 PERI:(DE-600)2006039-7 |n 46 |p 9559 - 9565 |t The journal of physical chemistry |v 126 |y 2022 |x 1520-6106 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/943378/files/acs.jpcb.2c05728.pdf |y Restricted |
| 856 | 4 | _ | |y Published on 2022-11-14. Available in OpenAccess from 2023-11-14. |u https://juser.fz-juelich.de/record/943378/files/Authors%27%20version.docx |
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