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@ARTICLE{Palm:9436,
      author       = {Palm, C. and Axer, M. and Gräßel, D. and Dammers, J. and
                      Lindemeyer, J. and Zilles, K. and Pietrzyk, U. and Amunts,
                      K.},
      title        = {{T}owards ultra-high resolution fibre tract mapping of the
                      human brain - registration of polarised light images and
                      reorientation of fibre vectors},
      journal      = {Frontiers in human neuroscience},
      volume       = {4},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {PreJuSER-9436},
      pages        = {1-16},
      year         = {2010},
      note         = {The authors would like to thank M. Cremer, Research Centre
                      Julich, Germany, as well as U. Blohm and U. Opfermann,
                      University Dusseldorf, Germany, for the brain preparation.
                      We also thank J. Hipwell, Centre of Medical Image Computing
                      (CMIC), University College London, GB, for providing the
                      vector visualisation software. This work was partly
                      supported by the Initiative and Network Fund of the
                      Helmholtz Association within the Helmholtz Alliance on
                      Systems Biology.},
      abstract     = {Polarised light imaging (PLI) utilises the birefringence of
                      the myelin sheaths in order to visualise the orientation of
                      nerve fibres in microtome sections of adult human
                      post-mortem brains at ultra-high spatial resolution. The
                      preparation of post-mortem brains for PLI involves fixation,
                      freezing and cutting into 100-mum-thick sections. Hence,
                      geometrical distortions of histological sections are
                      inevitable and have to be removed for 3D reconstruction and
                      subsequent fibre tracking. We here present a processing
                      pipeline for 3D reconstruction of these sections using PLI
                      derived multimodal images of post-mortem brains. Blockface
                      images of the brains were obtained during cutting; they
                      serve as reference data for alignment and elimination of
                      distortion artefacts. In addition to the spatial image
                      transformation, fibre orientation vectors were reoriented
                      using the transformation fields, which consider both affine
                      and subsequent non-linear registration. The application of
                      this registration and reorientation approach results in a
                      smooth fibre vector field, which reflects brain morphology.
                      PLI combined with 3D reconstruction and fibre tracking is a
                      powerful tool for human brain mapping. It can also serve as
                      an independent method for evaluating in vivo fibre
                      tractography.},
      keywords     = {J (WoSType)},
      cin          = {INM-2 / INM-1 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89574 - Theory, modelling and simulation (POF2-89574)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89574},
      shelfmark    = {Neurosciences / Psychology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20461231},
      pmc          = {pmc:PMC2866503},
      UT           = {WOS:000277978200007},
      doi          = {10.3389/neuro.09.009.2010},
      url          = {https://juser.fz-juelich.de/record/9436},
}