guest ::
| Home > Publications database > Peptide modified nanocarriers for selective targeting of bombesin receptors > print |
| Home > Publications database > Peptide modified nanocarriers for selective targeting of bombesin receptors > print |
| 001 | 9565 | ||
| 005 | 20240619091746.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:20567774 |
| 024 | 7 | _ | |2 DOI |a 10.1039/b923147a |
| 024 | 7 | _ | |2 WOS |a WOS:000277315800015 |
| 024 | 7 | _ | |2 MLZ |a AccardoMMMPTRAAAM2010 |
| 037 | _ | _ | |a PreJuSER-9565 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 540 |
| 084 | _ | _ | |2 WoS |a Biochemistry & Molecular Biology |
| 100 | 1 | _ | |0 P:(DE-HGF)0 |a Accardo, A. |b 0 |
| 245 | _ | _ | |a Peptide modified nanocarriers for selective targeting of bombesin receptors |
| 260 | _ | _ | |a Cambridge |b Royal Society of Chemistry |c 2010 |
| 300 | _ | _ | |a 878 - 887 |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |0 20661 |a Molecular BioSystems |v 6 |x 1742-206X |y 5 |
| 500 | _ | _ | |a We thank Prof. Helmut Maecke, University Hospital Basel, Switzerland for the helpful discussions and suggestions. We are indebted to EMIL, European Molecular Imaging Laboratories, for financial support. Some of us (LP, GM, AR) wish to thank the Forschungszentrum Julich for provision of beam time. |
| 520 | _ | _ | |a The present work describes new supramolecular aggregates obtained by co-assembling two different amphiphilic molecules, one containing the bioactive bombesin peptide (BN), or a scramble sequence, and the other, the DOTA chelating agent, (C18)(2)DOTA, capable of forming stable complexes with the radioactive (111)In(III) isotope. The peptide in the amphiphilic monomer is spaced by the lipophilic moiety through ethoxylic spacers of different length: a shorter spacer with five units of dioxoethylene moieties in (C18)(2)L5-peptide, or a longer spacer consisting of a Peg3000 residue in (C18)(2)Peg3000-peptide. Structural characterization by SANS and DLS techniques indicates that, independently from the presence of the peptide containing monomer in the final composition, the predominant aggregates are liposomes of similar shape and size with a hydrodynamic radius R(h) around 200 nm and bilayer thickness, d, of 4 nm. In vitro data show specific binding of the (111)In-(C18)(2)DOTA/(C18)(2)L5-[7-14]BN 90:10 liposomes in receptor expressing cells. However, the presence of the Peg3000 unit on the external liposomal surface, could hide the peptide and prevent the receptor binding. In vivo experiments using (111)In-(C18)(2)DOTA/(C18)(2)L5-[7-14]BN show the expected biological behavior of aggregates of such size and molecular composition, moreover there is an increase in concentration of the GRPR targeting aggregate in the tumors compared to control at the 48 h time point evaluated (2.4% ID/g versus 1.6% ID/g). |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK505 |2 G:(DE-HGF) |a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |c P45 |x 0 |
| 536 | _ | _ | |0 G:(DE-Juel1)FUEK415 |a Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) |c P55 |x 1 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Cell Line, Tumor |
| 650 | _ | 2 | |2 MeSH |a Chelating Agents: chemistry |
| 650 | _ | 2 | |2 MeSH |a Heterocyclic Compounds, 1-Ring: chemistry |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Liposomes: chemistry |
| 650 | _ | 2 | |2 MeSH |a Models, Theoretical |
| 650 | _ | 2 | |2 MeSH |a Molecular Structure |
| 650 | _ | 2 | |2 MeSH |a Peptides: chemistry |
| 650 | _ | 2 | |2 MeSH |a Peptides: metabolism |
| 650 | _ | 2 | |2 MeSH |a Receptors, Bombesin: metabolism |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Chelating Agents |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Heterocyclic Compounds, 1-Ring |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Liposomes |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Peptides |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Receptors, Bombesin |
| 650 | _ | 7 | |0 60239-18-1 |2 NLM Chemicals |a 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid |
| 650 | _ | 7 | |2 WoSType |a J |
| 693 | _ | _ | |0 EXP:(DE-MLZ)KWS2-20140101 |1 EXP:(DE-MLZ)FRMII-20140101 |5 EXP:(DE-MLZ)KWS2-20140101 |6 EXP:(DE-MLZ)NL3ao-20140101 |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz |e KWS-2: Small angle scattering diffractometer |f NL3ao |x 0 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Mansi, R. |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Mirisco, A. |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Mangiapia, G. |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Paduano, L. |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Tesauro, D. |b 5 |
| 700 | 1 | _ | |0 P:(DE-Juel1)VDB4342 |a Radulescu, A. |b 6 |u FZJ |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Aurilio, M. |b 7 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Aloj, L. |b 8 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Arra, C. |b 9 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Morelli, G. |b 10 |
| 773 | _ | _ | |0 PERI:(DE-600)2188635-0 |a 10.1039/b923147a |g Vol. 6, p. 878 - 887 |p 878 - 887 |q 6<878 - 887 |t Molecular BioSystems |v 6 |x 1742-206X |y 2010 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1039/b923147a |
| 909 | C | O | |o oai:juser.fz-juelich.de:9565 |p VDB |
| 913 | 1 | _ | |0 G:(DE-Juel1)FUEK505 |b Schlüsseltechnologien |k P45 |l Biologische Informationsverarbeitung |v BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |x 0 |
| 913 | 1 | _ | |0 G:(DE-Juel1)FUEK415 |b Struktur der Materie |k P55 |l Großgeräteforschung mit Photonen, Neutronen und Ionen |v Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) |x 1 |
| 913 | 2 | _ | |0 G:(DE-HGF)POF3-623 |1 G:(DE-HGF)POF3-620 |2 G:(DE-HGF)POF3-600 |a DE-HGF |b Forschungsbereich Materie |l In-house research on the structure, dynamics and function of matter |v Neutrons for Research on Condensed Matter |x 0 |
| 914 | 1 | _ | |y 2010 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |0 I:(DE-Juel1)VDB784 |d 31.12.2010 |g IFF |k IFF-4 |l Streumethoden |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)VDB785 |d 31.12.2010 |g IFF |k IFF-5 |l Neutronenstreuung |x 1 |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-20121112 |k Jülich Centre for Neutron Science JCNS (JCNS) ; JCNS |l JCNS |x 2 |
| 970 | _ | _ | |a VDB:(DE-Juel1)119485 |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a ConvertedRecord |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a I:(DE-Juel1)PGI-4-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)ICS-1-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-2-20110106 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-SNS-20110128 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-ILL-20110128 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-2-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-8-20200312 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)PGI-4-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)ICS-1-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-2-20110106 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-SNS-20110128 |
| 981 | _ | _ | |a I:(DE-Juel1)JCNS-ILL-20110128 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|