TY  - JOUR
AU  - Kurth, F.
AU  - Eickhoff, S. B.
AU  - Schleicher, A.
AU  - Hoemke, L.
AU  - Zilles, K.
AU  - Amunts, K.
TI  - Cytoarchitecture and Probabilistic Maps of the Human Posterior Insular Cortex.
JO  - Cerebral cortex
VL  - 20
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - PreJuSER-9710
SP  - 1448 - 1461
PY  - 2010
N1  - Human Brain Project/Neuroinformatics research by the National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Helmholtz Alliance "Systems Biology" the "Human Brain Model" (WP02 P03 to K. Z. and S. E.).
AB  - The human posterior insula was shown to respond to a wide variety of stimulation paradigms (e.g. pain, somatosensory, or auditory processing) in functional imaging experiments. Although various anatomical maps of this region have been published over the last century, these schemes show variable results. Moreover, none can directly be integrated with functional imaging data. Hence, our current knowledge about the structure-function relationships in this region remains limited. We therefore remapped the posterior part of the human insular cortex in 10 postmortem brains using an observer-independent approach. This analysis revealed the existence of 3 cytoarchitectonically distinct areas in the posterior insula. The examined brains were then 3D reconstructed and spatially normalized to the Montreal Neurological Institute single-subject template. Probabilistic maps for each area were calculated by superimposing the individual delineations, and a cytoarchitectonic summary map was computed to chart the regional architectonic organization. These maps can be used to identify the anatomical correlates of functional activations observed in neuroimaging studies and to understand the microstructural correlates of the functional segregation of the human posterior insula.
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Brain Mapping: methods
KW  - Cerebral Cortex: cytology
KW  - Cerebral Cortex: physiology
KW  - Female
KW  - Functional Laterality: physiology
KW  - Humans
KW  - Imaging, Three-Dimensional
KW  - Male
KW  - Middle Aged
KW  - Models, Statistical
KW  - Nerve Fibers, Myelinated: physiology
KW  - Neural Pathways: anatomy & histology
KW  - Neural Pathways: cytology
KW  - Neural Pathways: physiology
KW  - Neurons: cytology
KW  - Neurons: physiology
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:19822572
C2  - pmc:PMC2871375
UR  - <Go to ISI:>//WOS:000277985800018
DO  - DOI:10.1093/cercor/bhp208
UR  - https://juser.fz-juelich.de/record/9710
ER  -