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@ARTICLE{Rueger:9719,
      author       = {Rueger, M.A. and Backes, H. and Walberer, M. and Nleumaier,
                      B. and Ullrich, R. and Simar, M.L. and EMig, B. and Fink, G.
                      R. and Hoehn, M. and Graf, R. and Schroeter, M.},
      title        = {{N}oninvasive imaging of endogenus neural stem cell
                      mobilization in vivo using positron emission tomography},
      journal      = {The journal of neuroscience},
      volume       = {30},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {PreJuSER-9719},
      pages        = {6454 - 6460},
      year         = {2010},
      note         = {This work was supported by the Koeln Fortune
                      Program/Faculty of Medicine, University of Cologne, Germany
                      (144/2007).},
      abstract     = {Neural stem cells reside in two major niches in the adult
                      brain [i.e., the subventricular zone (SVZ) and the dentate
                      gyrus of the hippocampus]. Insults to the brain such as
                      cerebral ischemia result in a physiological mobilization of
                      endogenous neural stem cells. Since recent studies showed
                      that pharmacological stimulation can be used to expand the
                      endogenous neural stem cell niche, hope has been raised to
                      enhance the brain's own regenerative capacity. For the
                      evaluation of such novel therapeutic approaches,
                      longitudinal and intraindividual monitoring of the
                      endogenous neural stem cell niche would be required.
                      However, to date no conclusive imaging technique has been
                      established. We used positron emission tomography (PET) and
                      the radiotracer 3'-deoxy-3'-[(18)F]fluoro-l-thymidine
                      ([(18)F]FLT) that enables imaging and measuring of
                      proliferation to noninvasively detect endogenous neural stem
                      cells in the normal and diseased adult rat brain in vivo.
                      This method indeed visualized neural stem cell niches in the
                      living rat brain, identified as increased [(18)F]FLT-binding
                      in the SVZ and the hippocampus. Focal cerebral ischemia and
                      subsequent damage of the blood-brain barrier did not
                      interfere with the capability of [(18)F]FLT-PET to visualize
                      neural stem cell mobilization. Moreover, [(18)F]FLT-PET
                      allowed for an in vivo quantification of increased neural
                      stem cell mobilization caused by pharmacological stimulation
                      or by focal cerebral ischemia. The data suggest that
                      noninvasive longitudinal monitoring and quantification of
                      endogenous neural stem cell activation in the brain is
                      feasible and that [(18)F]FLT-PET could be used to monitor
                      the effects of drugs aimed at expanding the neural stem cell
                      niche.},
      keywords     = {Animals / Brain: drug effects / Brain: embryology / Brain:
                      metabolism / Brain: physiology / Brain: radionuclide imaging
                      / Brain Ischemia: metabolism / Brain Ischemia:
                      physiopathology / Cell Movement: drug effects / Cell
                      Movement: physiology / Cell Proliferation: drug effects /
                      Cells, Cultured / Dideoxynucleosides: metabolism /
                      Fibroblast Growth Factor 2: pharmacology / Insulin:
                      pharmacology / Intracellular Signaling Peptides and Proteins
                      / Lateral Ventricles: drug effects / Lateral Ventricles:
                      physiology / Membrane Proteins: pharmacology / Neurons:
                      metabolism / Neurons: physiology / Positron-Emission
                      Tomography: methods / Rats / Stem Cells: metabolism / Stem
                      Cells: physiology / Dideoxynucleosides (NLM Chemicals) /
                      Insulin (NLM Chemicals) / Intracellular Signaling Peptides
                      and Proteins (NLM Chemicals) / Membrane Proteins (NLM
                      Chemicals) / delta protein (NLM Chemicals) / Fibroblast
                      Growth Factor 2 (NLM Chemicals) / alovudine (NLM Chemicals)
                      / J (WoSType)},
      cin          = {INM-3},
      ddc          = {590},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20445071},
      UT           = {WOS:000277358300031},
      doi          = {10.1523/JNEUROSCI.6092-09.2010},
      url          = {https://juser.fz-juelich.de/record/9719},
}