Home > Publications database > Noninvasive imaging of endogenus neural stem cell mobilization in vivo using positron emission tomography > print

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024 7 _ |a pmid:20445071
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024 7 _ |a 10.1523/JNEUROSCI.6092-09.2010
|2 DOI
024 7 _ |a WOS:000277358300031
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024 7 _ |a 2128/20585
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037 _ _ |a PreJuSER-9719
041 _ _ |a eng
082 _ _ |a 590
084 _ _ |2 WoS
|a Neurosciences
100 1 _ |0 P:(DE-HGF)0
|a Rueger, M.A.
|b 0
245 _ _ |a Noninvasive imaging of endogenus neural stem cell mobilization in vivo using positron emission tomography
260 _ _ |a Washington, DC
|b Soc.
|c 2010
300 _ _ |a 6454 - 6460
336 7 _ |a Journal Article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
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440 _ 0 |0 3603
|a Journal of Neuroscience
|v 30
|x 0270-6474
|y 18
500 _ _ |a This work was supported by the Koeln Fortune Program/Faculty of Medicine, University of Cologne, Germany (144/2007).
520 _ _ |a Neural stem cells reside in two major niches in the adult brain [i.e., the subventricular zone (SVZ) and the dentate gyrus of the hippocampus]. Insults to the brain such as cerebral ischemia result in a physiological mobilization of endogenous neural stem cells. Since recent studies showed that pharmacological stimulation can be used to expand the endogenous neural stem cell niche, hope has been raised to enhance the brain's own regenerative capacity. For the evaluation of such novel therapeutic approaches, longitudinal and intraindividual monitoring of the endogenous neural stem cell niche would be required. However, to date no conclusive imaging technique has been established. We used positron emission tomography (PET) and the radiotracer 3'-deoxy-3'-[(18)F]fluoro-l-thymidine ([(18)F]FLT) that enables imaging and measuring of proliferation to noninvasively detect endogenous neural stem cells in the normal and diseased adult rat brain in vivo. This method indeed visualized neural stem cell niches in the living rat brain, identified as increased [(18)F]FLT-binding in the SVZ and the hippocampus. Focal cerebral ischemia and subsequent damage of the blood-brain barrier did not interfere with the capability of [(18)F]FLT-PET to visualize neural stem cell mobilization. Moreover, [(18)F]FLT-PET allowed for an in vivo quantification of increased neural stem cell mobilization caused by pharmacological stimulation or by focal cerebral ischemia. The data suggest that noninvasive longitudinal monitoring and quantification of endogenous neural stem cell activation in the brain is feasible and that [(18)F]FLT-PET could be used to monitor the effects of drugs aimed at expanding the neural stem cell niche.
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|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |0 G:(DE-HGF)POF2-89572
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Brain: drug effects
650 _ 2 |2 MeSH
|a Brain: embryology
650 _ 2 |2 MeSH
|a Brain: metabolism
650 _ 2 |2 MeSH
|a Brain: physiology
650 _ 2 |2 MeSH
|a Brain: radionuclide imaging
650 _ 2 |2 MeSH
|a Brain Ischemia: metabolism
650 _ 2 |2 MeSH
|a Brain Ischemia: physiopathology
650 _ 2 |2 MeSH
|a Cell Movement: drug effects
650 _ 2 |2 MeSH
|a Cell Movement: physiology
650 _ 2 |2 MeSH
|a Cell Proliferation: drug effects
650 _ 2 |2 MeSH
|a Cells, Cultured
650 _ 2 |2 MeSH
|a Dideoxynucleosides: metabolism
650 _ 2 |2 MeSH
|a Fibroblast Growth Factor 2: pharmacology
650 _ 2 |2 MeSH
|a Insulin: pharmacology
650 _ 2 |2 MeSH
|a Intracellular Signaling Peptides and Proteins
650 _ 2 |2 MeSH
|a Lateral Ventricles: drug effects
650 _ 2 |2 MeSH
|a Lateral Ventricles: physiology
650 _ 2 |2 MeSH
|a Membrane Proteins: pharmacology
650 _ 2 |2 MeSH
|a Neurons: metabolism
650 _ 2 |2 MeSH
|a Neurons: physiology
650 _ 2 |2 MeSH
|a Positron-Emission Tomography: methods
650 _ 2 |2 MeSH
|a Rats
650 _ 2 |2 MeSH
|a Stem Cells: metabolism
650 _ 2 |2 MeSH
|a Stem Cells: physiology
650 _ 7 |0 0
|2 NLM Chemicals
|a Dideoxynucleosides
650 _ 7 |0 0
|2 NLM Chemicals
|a Insulin
650 _ 7 |0 0
|2 NLM Chemicals
|a Intracellular Signaling Peptides and Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a Membrane Proteins
650 _ 7 |0 0
|2 NLM Chemicals
|a delta protein
650 _ 7 |0 103107-01-3
|2 NLM Chemicals
|a Fibroblast Growth Factor 2
650 _ 7 |0 25526-93-6
|2 NLM Chemicals
|a alovudine
650 _ 7 |2 WoSType
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700 1 _ |0 P:(DE-HGF)0
|a Backes, H.
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700 1 _ |0 P:(DE-HGF)0
|a Walberer, M.
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700 1 _ |0 P:(DE-HGF)0
|a Nleumaier, B.
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700 1 _ |0 P:(DE-HGF)0
|a Ullrich, R.
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700 1 _ |0 P:(DE-HGF)0
|a Simar, M.L.
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700 1 _ |0 P:(DE-HGF)0
|a EMig, B.
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700 1 _ |0 P:(DE-Juel1)131720
|a Fink, G. R.
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|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Hoehn, M.
|b 8
700 1 _ |0 P:(DE-Juel1)VDB89964
|a Graf, R.
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|u FZJ
700 1 _ |0 P:(DE-HGF)0
|a Schroeter, M.
|b 10
773 _ _ |0 PERI:(DE-600)1475274-8
|a 10.1523/JNEUROSCI.6092-09.2010
|g Vol. 30, p. 6454 - 6460
|p 6454 - 6460
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|t The @journal of neuroscience
|v 30
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856 7 _ |u http://dx.doi.org/10.1523/JNEUROSCI.6092-09.2010
856 4 _ |u https://juser.fz-juelich.de/record/9719/files/6454.full.pdf
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