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@ARTICLE{Schroeter:972038,
      author       = {Schroeter, Matthias L. and Godulla, Jannis and Thiel,
                      Friederike and Taskin, Birol and Beutner, Frank and Dubovoy,
                      Vladimir K. and Teren, Andrej and Camilleri, Julia and
                      Eickhoff, Simon and Villringer, Arno and Mueller, Karsten},
      title        = {{H}eart failure decouples the precuneus in interaction with
                      social cognition and executive functions},
      journal      = {Scientific reports},
      volume       = {13},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2023-01047},
      pages        = {1236},
      year         = {2023},
      abstract     = {Aging increases the risk to develop Alzheimer's disease.
                      Cardiovascular diseases might accelerate this process. Our
                      study aimed at investigating the impact of heart failure on
                      brain connectivity using functional magnetic resonance
                      imaging at resting state. Here we show brain connectivity
                      alterations related to heart failure and cognitive
                      performance. Heart failure decreases brain connectivity in
                      the precuneus. Precuneus dysconnectivity was associated with
                      biomarkers of heart failure-left ventricular ejection
                      fraction and N-terminal prohormone of brain natriuretic
                      peptide-and cognitive performance, predominantly executive
                      function. Meta-analytical data-mining approaches-conducted
                      in the BrainMap and Neurosynth databases-revealed that
                      social and executive cognitive functions are mainly
                      associated with those neural networks. Remarkably, the
                      precuneus, as identified in our study in a mid-life cohort,
                      represents one central functional hub affected by
                      Alzheimer's disease. A long-term follow-up investigation in
                      our cohort after approximately nine years revealed more
                      severe cognitive impairment in the group with heart failure
                      than controls, where social cognition was the cognitive
                      domain mainly affected, and not memory such as in
                      Alzheimer's disease. In sum, our results indicate
                      consistently an association between heart failure and
                      decoupling of the precuneus from other brain regions being
                      associated with social and executive functions. Further
                      longitudinal studies are warranted elucidating
                      etiopathological mechanisms.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36690723},
      UT           = {WOS:000954571900022},
      doi          = {10.1038/s41598-023-28338-0},
      url          = {https://juser.fz-juelich.de/record/972038},
}