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@ARTICLE{Gronewold:972132,
      author       = {Gronewold, Janine and Jokisch, Martha and Schramm, Sara and
                      Himpfen, Heiko and Ginster, Theresa and Tenhagen, Isabell
                      and Doeppner, Thorsten R. and Jockwitz, Christiane and
                      Miller, Tatiana and Lehmann, Nils and Moebus, Susanne and
                      Jöckel, Karl-Heinz and Erbel, Raimund and Caspers, Svenja
                      and Hermann, Dirk M.},
      title        = {{A}ssociation of regional white matter hyperintensities
                      with hypertension and cognition in the population‐based
                      1000{BRAINS} study},
      journal      = {European journal of neurology},
      volume       = {30},
      number       = {5},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science},
      reportid     = {FZJ-2023-01091},
      pages        = {1174-1190},
      year         = {2023},
      abstract     = {BackgroundWhite matter hyperintensities of presumed
                      vascular origin (WMH) are frequent in cerebral magnetic
                      resonance imaging of older people. They are promoted by
                      vascular risk factors, especially hypertension, and are
                      associated with cognitive deficits at the group level. It
                      has been suggested that not only the severity, but also the
                      location, of lesions might critically influence cognitive
                      deficits and represent different pathologies.MethodsIn 560
                      participants (65.2 ± 7.5 years, $51.4\%$ males) of
                      the population-based 1000BRAINS study, we analyzed the
                      association of regional WMH using Fazekas scoring separately
                      for cerebral lobes, with hypertension and
                      cognition.ResultsWMH most often affected the frontal lobe
                      $(83.7\%$ score >0), followed by the parietal $(75.8\%),$
                      temporal $(32.7\%),$ and occipital lobe $(7.3\%).$ Higher
                      Fazekas scores in the frontal, parietal, and temporal lobe
                      were associated with higher blood pressure and
                      antihypertensive treatment in unadjusted ordinal regression
                      models and in models adjusted for age, sex, and vascular
                      risk factors (e.g., age- and sex-adjusted odds ratio = 1.14,
                      $95\%$ confidence interval = 1.03–1.25 for the association
                      of frontal lobe WMH Fazekas score with systolic blood
                      pressure [SBP] [per 10 mm Hg]; 1.13 [1.02–1.23] for the
                      association of parietal lobe score with SBP; 1.72
                      [1.19–2.48] for the association of temporal lobe score
                      with antihypertensive medications). In linear regressions,
                      higher frontal lobe scores were associated with lower
                      performance in executive function and non-verbal memory, and
                      higher parietal lobe scores were associated with lower
                      performance in executive function, verbal-, and non-verbal
                      memory.ConclusionsHypertension promotes WMH in the frontal,
                      parietal, and temporal lobe. WMH in the frontal and parietal
                      lobe are associated with reduced executive function and
                      memory.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36702775},
      UT           = {WOS:000937044600001},
      doi          = {10.1111/ene.15716},
      url          = {https://juser.fz-juelich.de/record/972132},
}