000972159 001__ 972159
000972159 005__ 20240226075345.0
000972159 0247_ $$2doi$$a10.1093/plphys/kiac563
000972159 0247_ $$2ISSN$$a0032-0889
000972159 0247_ $$2ISSN$$a1532-2548
000972159 0247_ $$2Handle$$a2128/34418
000972159 0247_ $$2pmid$$a36493393
000972159 0247_ $$2WOS$$aWOS:000927167100001
000972159 037__ $$aFZJ-2023-01103
000972159 082__ $$a580
000972159 1001_ $$00000-0002-8806-0272$$aHornbergs, Jannik$$b0
000972159 245__ $$aSEC14-GOLD protein PATELLIN2 binds IRON-REGULATED TRANSPORTER1 linking root iron uptake to vitamin E
000972159 260__ $$aOxford$$bOxford University Press$$c2022
000972159 3367_ $$2DRIVER$$aarticle
000972159 3367_ $$2DataCite$$aOutput Types/Journal article
000972159 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1684222700_3440
000972159 3367_ $$2BibTeX$$aARTICLE
000972159 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000972159 3367_ $$00$$2EndNote$$aJournal Article
000972159 520__ $$aOrganisms require micronutrients, and Arabidopsis (Arabidopsis thaliana) IRON-REGULATED TRANSPORTER1 (IRT1) is essential for iron (Fe2+) acquisition into root cells. Uptake of reactive Fe2+ exposes cells to the risk of membrane lipid peroxidation. Surprisingly little is known about how this is avoided. IRT1 activity is controlled by an intracellular variable region (IRT1vr) that acts as a regulatory protein interaction platform. Here, we describe that IRT1vr interacted with peripheral plasma membrane SEC14-Golgi dynamics (SEC14-GOLD) protein PATELLIN2 (PATL2). SEC14 proteins bind lipophilic substrates and transport or present them at the membrane. To date, no direct roles have been attributed to SEC14 proteins in Fe import. PATL2 affected root Fe acquisition responses, interacted with ROS response proteins in roots, and alleviated root lipid peroxidation. PATL2 had high affinity in vitro for the major lipophilic antioxidant vitamin E compound α-tocopherol. Molecular dynamics simulations provided insight into energetic constraints and the orientation and stability of the PATL2-ligand interaction in atomic detail. Hence, this work highlights a compelling mechanism connecting vitamin E with root metal ion transport at the plasma membrane with the participation of an IRT1-interacting and α-tocopherol-binding SEC14 protein.
000972159 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
000972159 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
000972159 7001_ $$00000-0003-0476-2160$$aMontag, Karolin$$b1
000972159 7001_ $$0P:(DE-Juel1)174397$$aLoschwitz, Jennifer$$b2
000972159 7001_ $$00000-0003-3496-5516$$aMohr, Inga$$b3
000972159 7001_ $$00000-0003-2448-0611$$aPoschmann, Gereon$$b4
000972159 7001_ $$0P:(DE-HGF)0$$aSchnake, Anika$$b5
000972159 7001_ $$00000-0002-8820-7211$$aGratz, Regina$$b6
000972159 7001_ $$00000-0002-3104-6795$$aBrumbarova, Tzvetina$$b7
000972159 7001_ $$00000-0003-1330-5121$$aEutebach, Monique$$b8
000972159 7001_ $$00000-0002-5014-6812$$aAngrand, Kalina$$b9
000972159 7001_ $$0P:(DE-HGF)0$$aFink-Straube, Claudia$$b10
000972159 7001_ $$0P:(DE-HGF)0$$aStühler, Kai$$b11
000972159 7001_ $$00000-0002-8703-5403$$aZeier, Jürgen$$b12
000972159 7001_ $$00000-0003-0115-6405$$aHartmann, Laura$$b13
000972159 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b14
000972159 7001_ $$00000-0001-7909-4123$$aIvanov, Rumen$$b15
000972159 7001_ $$00000-0002-0404-4532$$aBauer, Petra$$b16$$eCorresponding author
000972159 773__ $$0PERI:(DE-600)2004346-6$$a10.1093/plphys/kiac563$$gp. kiac563$$n1$$p504–526$$tPlant physiology$$v192$$x0032-0889$$y2022
000972159 8564_ $$uhttps://juser.fz-juelich.de/record/972159/files/kiac563.pdf$$yOpenAccess
000972159 909CO $$ooai:juser.fz-juelich.de:972159$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000972159 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)174397$$aForschungszentrum Jülich$$b2$$kFZJ
000972159 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)132024$$aForschungszentrum Jülich$$b14$$kFZJ
000972159 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
000972159 9141_ $$y2023
000972159 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bPLANT PHYSIOL : 2021$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bPLANT PHYSIOL : 2021$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000972159 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2022-11-17
000972159 915__ $$0StatID:(DE-HGF)0430$$2StatID$$aNational-Konsortium$$d2022-11-17$$wger
000972159 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-17
000972159 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000972159 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-17
000972159 920__ $$lyes
000972159 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
000972159 980__ $$ajournal
000972159 980__ $$aVDB
000972159 980__ $$aUNRESTRICTED
000972159 980__ $$aI:(DE-Juel1)IBI-7-20200312
000972159 9801_ $$aFullTexts