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000009742 0247_ $$2DOI$$a10.1089/rej.2009.0932
000009742 0247_ $$2WOS$$aWOS:000277602200020
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000009742 041__ $$aeng
000009742 082__ $$a610
000009742 084__ $$2WoS$$aGeriatrics & Gerontology
000009742 1001_ $$0P:(DE-Juel1)VDB89563$$aLüers, L.$$b0$$uFZJ
000009742 245__ $$aAmyloid formation: Age-related mechanism in Creutzfeldt-Jakob disease?
000009742 260__ $$aLarchmont, NY$$bLiebert$$c2010
000009742 300__ $$a
000009742 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000009742 3367_ $$2DataCite$$aOutput Types/Journal article
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000009742 440_0 $$018202$$aRejuvenation Research$$v13$$x1549-1684$$y2
000009742 500__ $$aRecord converted from VDB: 12.11.2012
000009742 520__ $$aProtein aggregation occurs in many age-related neurodegenerative diseases, where it can lead to deposits of naturally occurring proteins in the brain. In case of Creutzfeldt-Jakob disease (CJD), these deposits consist of prion protein (PrP). CJD has three etiologies: spontaneous, genetic, or caused by infection. A polymorphism within the PrP gene is associated with susceptibility of infection. The main event in prion diseases is the conversion of PrP from its naturally occurring isoform to its disease-associated isoform. Here, we present the adaption of a previously reported in vitro conversion system based on hamster recombinant PrP to analyze amyloid fibril formation of human recombinant PrP. We further compare the aggregation characteristics of the human PrP according to the polymorphism variants M129 and V129.
000009742 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000009742 536__ $$0G:(DE-Juel1)FUEK505$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x1
000009742 588__ $$aDataset connected to Web of Science, Pubmed
000009742 650_2 $$2MeSH$$aAging: metabolism
000009742 650_2 $$2MeSH$$aAging: physiology
000009742 650_2 $$2MeSH$$aAmyloid: metabolism
000009742 650_2 $$2MeSH$$aCircular Dichroism
000009742 650_2 $$2MeSH$$aCongo Red: pharmacology
000009742 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: etiology
000009742 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: metabolism
000009742 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: pathology
000009742 650_2 $$2MeSH$$aHumans
000009742 650_2 $$2MeSH$$aMicroscopy, Electron, Transmission
000009742 650_2 $$2MeSH$$aModels, Biological
000009742 650_2 $$2MeSH$$aPrPSc Proteins: chemistry
000009742 650_2 $$2MeSH$$aPrPSc Proteins: metabolism
000009742 650_2 $$2MeSH$$aRecombinant Proteins: analysis
000009742 650_2 $$2MeSH$$aRecombinant Proteins: chemistry
000009742 650_2 $$2MeSH$$aRecombinant Proteins: metabolism
000009742 650_2 $$2MeSH$$aStaining and Labeling
000009742 650_2 $$2MeSH$$aThiazoles: pharmacology
000009742 650_7 $$00$$2NLM Chemicals$$aAmyloid
000009742 650_7 $$00$$2NLM Chemicals$$aPrPSc Proteins
000009742 650_7 $$00$$2NLM Chemicals$$aRecombinant Proteins
000009742 650_7 $$00$$2NLM Chemicals$$aThiazoles
000009742 650_7 $$02390-54-7$$2NLM Chemicals$$athioflavin T
000009742 650_7 $$0573-58-0$$2NLM Chemicals$$aCongo Red
000009742 650_7 $$2WoSType$$aJ
000009742 7001_ $$0P:(DE-HGF)0$$aPanza, G.$$b1
000009742 7001_ $$0P:(DE-Juel1)VDB65871$$aHenke, F.$$b2$$uFZJ
000009742 7001_ $$0P:(DE-HGF)0$$aAygenim, T.$$b3
000009742 7001_ $$0P:(DE-HGF)0$$aWeiß, J.$$b4
000009742 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b5$$uFZJ
000009742 7001_ $$0P:(DE-Juel1)VDB65870$$aBirkmann, E.$$b6$$uFZJ
000009742 773__ $$0PERI:(DE-600)2155984-3$$a10.1089/rej.2009.0932$$gVol. 13$$q13$$tRejuvenation research$$v13$$x1549-1684$$y2010
000009742 8567_ $$uhttp://dx.doi.org/10.1089/rej.2009.0932
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000009742 9131_ $$0G:(DE-Juel1)FUEK505$$bSchlüsseltechnologien$$kP45$$lBiologische Informationsverarbeitung$$vBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$x1
000009742 9132_ $$0G:(DE-HGF)POF3-553$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lBioSoft  Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vPhysical Basis of Diseases$$x0
000009742 9141_ $$y2010
000009742 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000009742 9201_ $$0I:(DE-Juel1)VDB942$$d31.12.2010$$gISB$$kISB-3$$lStrukturbiochemie$$x0
000009742 9201_ $$0I:(DE-82)080012_20140620$$gJARA$$kJARA-HPC$$lJülich Aachen Research Alliance - High-Performance Computing$$x1
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