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| 001 | 9742 | ||
| 005 | 20200402205832.0 | ||
| 024 | 7 | _ | |2 pmid |a pmid:20017612 |
| 024 | 7 | _ | |2 DOI |a 10.1089/rej.2009.0932 |
| 024 | 7 | _ | |2 WOS |a WOS:000277602200020 |
| 037 | _ | _ | |a PreJuSER-9742 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 084 | _ | _ | |2 WoS |a Geriatrics & Gerontology |
| 100 | 1 | _ | |a Lüers, L. |b 0 |u FZJ |0 P:(DE-Juel1)VDB89563 |
| 245 | _ | _ | |a Amyloid formation: Age-related mechanism in Creutzfeldt-Jakob disease? |
| 260 | _ | _ | |a Larchmont, NY |b Liebert |c 2010 |
| 300 | _ | _ | |a |
| 336 | 7 | _ | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a article |2 DRIVER |
| 440 | _ | 0 | |a Rejuvenation Research |x 1549-1684 |0 18202 |y 2 |v 13 |
| 500 | _ | _ | |a Record converted from VDB: 12.11.2012 |
| 520 | _ | _ | |a Protein aggregation occurs in many age-related neurodegenerative diseases, where it can lead to deposits of naturally occurring proteins in the brain. In case of Creutzfeldt-Jakob disease (CJD), these deposits consist of prion protein (PrP). CJD has three etiologies: spontaneous, genetic, or caused by infection. A polymorphism within the PrP gene is associated with susceptibility of infection. The main event in prion diseases is the conversion of PrP from its naturally occurring isoform to its disease-associated isoform. Here, we present the adaption of a previously reported in vitro conversion system based on hamster recombinant PrP to analyze amyloid fibril formation of human recombinant PrP. We further compare the aggregation characteristics of the human PrP according to the polymorphism variants M129 and V129. |
| 536 | _ | _ | |a Funktion und Dysfunktion des Nervensystems |c P33 |2 G:(DE-HGF) |0 G:(DE-Juel1)FUEK409 |x 0 |
| 536 | _ | _ | |a BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |c P45 |0 G:(DE-Juel1)FUEK505 |x 1 |
| 588 | _ | _ | |a Dataset connected to Web of Science, Pubmed |
| 650 | _ | 2 | |2 MeSH |a Aging: metabolism |
| 650 | _ | 2 | |2 MeSH |a Aging: physiology |
| 650 | _ | 2 | |2 MeSH |a Amyloid: metabolism |
| 650 | _ | 2 | |2 MeSH |a Circular Dichroism |
| 650 | _ | 2 | |2 MeSH |a Congo Red: pharmacology |
| 650 | _ | 2 | |2 MeSH |a Creutzfeldt-Jakob Syndrome: etiology |
| 650 | _ | 2 | |2 MeSH |a Creutzfeldt-Jakob Syndrome: metabolism |
| 650 | _ | 2 | |2 MeSH |a Creutzfeldt-Jakob Syndrome: pathology |
| 650 | _ | 2 | |2 MeSH |a Humans |
| 650 | _ | 2 | |2 MeSH |a Microscopy, Electron, Transmission |
| 650 | _ | 2 | |2 MeSH |a Models, Biological |
| 650 | _ | 2 | |2 MeSH |a PrPSc Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a PrPSc Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Recombinant Proteins: analysis |
| 650 | _ | 2 | |2 MeSH |a Recombinant Proteins: chemistry |
| 650 | _ | 2 | |2 MeSH |a Recombinant Proteins: metabolism |
| 650 | _ | 2 | |2 MeSH |a Staining and Labeling |
| 650 | _ | 2 | |2 MeSH |a Thiazoles: pharmacology |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Amyloid |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a PrPSc Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Recombinant Proteins |
| 650 | _ | 7 | |0 0 |2 NLM Chemicals |a Thiazoles |
| 650 | _ | 7 | |0 2390-54-7 |2 NLM Chemicals |a thioflavin T |
| 650 | _ | 7 | |0 573-58-0 |2 NLM Chemicals |a Congo Red |
| 650 | _ | 7 | |a J |2 WoSType |
| 700 | 1 | _ | |a Panza, G. |b 1 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Henke, F. |b 2 |u FZJ |0 P:(DE-Juel1)VDB65871 |
| 700 | 1 | _ | |a Aygenim, T. |b 3 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Weiß, J. |b 4 |0 P:(DE-HGF)0 |
| 700 | 1 | _ | |a Willbold, D. |b 5 |u FZJ |0 P:(DE-Juel1)132029 |
| 700 | 1 | _ | |a Birkmann, E. |b 6 |u FZJ |0 P:(DE-Juel1)VDB65870 |
| 773 | _ | _ | |a 10.1089/rej.2009.0932 |g Vol. 13 |q 13 |0 PERI:(DE-600)2155984-3 |t Rejuvenation research |v 13 |y 2010 |x 1549-1684 |
| 856 | 7 | _ | |u http://dx.doi.org/10.1089/rej.2009.0932 |
| 909 | C | O | |o oai:juser.fz-juelich.de:9742 |p VDB |
| 913 | 1 | _ | |k P33 |v Funktion und Dysfunktion des Nervensystems |l Funktion und Dysfunktion des Nervensystems |b Gesundheit |0 G:(DE-Juel1)FUEK409 |x 0 |
| 913 | 1 | _ | |k P45 |v BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung |l Biologische Informationsverarbeitung |b Schlüsseltechnologien |0 G:(DE-Juel1)FUEK505 |x 1 |
| 913 | 2 | _ | |a DE-HGF |b Key Technologies |l BioSoft Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences |1 G:(DE-HGF)POF3-550 |0 G:(DE-HGF)POF3-553 |2 G:(DE-HGF)POF3-500 |v Physical Basis of Diseases |x 0 |
| 914 | 1 | _ | |y 2010 |
| 915 | _ | _ | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed |
| 920 | 1 | _ | |d 31.12.2010 |g ISB |k ISB-3 |l Strukturbiochemie |0 I:(DE-Juel1)VDB942 |x 0 |
| 920 | 1 | _ | |0 I:(DE-82)080012_20140620 |k JARA-HPC |l Jülich Aachen Research Alliance - High-Performance Computing |g JARA |x 1 |
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| 980 | _ | _ | |a ConvertedRecord |
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| 980 | _ | _ | |a I:(DE-Juel1)ICS-6-20110106 |
| 980 | _ | _ | |a I:(DE-82)080012_20140620 |
| 980 | _ | _ | |a UNRESTRICTED |
| 981 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
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| 981 | _ | _ | |a I:(DE-Juel1)VDB1346 |
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