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@ARTICLE{Onur:9820,
      author       = {Onur, O.A. and Schlaepfer, T.E. and Kukolja, J. and Bauer,
                      A. and Jeung, H. and Patin, A. and Otte, D.-M. and Shah, J.
                      N. and Maier, W. and Kendrick, K.M. and Fink, G. R. and
                      Hurlemann, R.},
      title        = {{T}he {N}-{M}ethyl-{D}-{A}spartate {R}eceptor {C}o-agonist
                      {D}-{C}ycloserine {F}acilitates {D}eclarative {L}earning and
                      {H}ippocampal {A}ctivity in {H}umans},
      journal      = {Biological psychiatry},
      volume       = {67},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-9820},
      pages        = {1205 - 1211},
      year         = {2010},
      note         = {RH was supported by a German Research Foundation Grant
                      (HU1302/2-2) and by a Starting Independent Researcher Grant
                      jointly provided by the Ministry of Innovation, Science,
                      Research and Technology of the State of North
                      Rhine-Westphalia and the University of Bonn. KMK was
                      supported by the Biotechnology and Biological Sciences
                      Research Council.},
      abstract     = {The N-methyl-D-aspartate receptor (NMDAR) is critical for
                      learning-related synaptic plasticity in amygdala and
                      hippocampus. As a consequence, there is considerable
                      interest in drugs targeting this receptor to help enhance
                      amygdala- and hippocampus-dependent learning. A promising
                      candidate in this respect is the NMDAR glycine-binding site
                      partial agonist D-cycloserine (DCS). Accumulating clinical
                      evidence indicates the efficacy of DCS in the facilitation
                      of amygdala-dependent fear extinction learning in patients
                      with phobic, social anxiety, panic, and obsessive-compulsive
                      disorder. An important unresolved question though is whether
                      the use of DCS can also facilitate hippocampus-dependent
                      declarative learning in healthy people as opposed to being
                      restricted to the fear memory domain.In the present study,
                      we investigated whether or not DCS can facilitate
                      hippocampus-dependent declarative learning. We have
                      therefore combined functional magnetic resonance imaging
                      with two different declarative learning tasks and
                      cytoarchitectonic probabilistic mapping of the hippocampus
                      and its major subdivisions in 40 healthy volunteers
                      administered either a 250 mg single oral dose of DCS or a
                      placebo.We found that DCS facilitates declarative learning
                      as well as blood-oxygen level dependent activity levels in
                      the probabilistically defined cornu ammonis region of the
                      hippocampus. The absence of activity changes in visual
                      control areas underscores the specific action of DCS in the
                      hippocampal cornu ammonis region.Our findings highlight
                      NMDAR glycine-binding site partial agonism as a promising
                      pharmacological mechanism for facilitating declarative
                      learning in healthy people.},
      keywords     = {Adult / Cycloserine: pharmacology / Female / Hippocampus:
                      drug effects / Hippocampus: physiology / Humans / Learning:
                      drug effects / Learning: physiology / Magnetic Resonance
                      Imaging: methods / Male / Photic Stimulation: methods /
                      Psychomotor Performance: drug effects / Psychomotor
                      Performance: physiology / Receptors, N-Methyl-D-Aspartate:
                      agonists / Receptors, N-Methyl-D-Aspartate (NLM Chemicals) /
                      Cycloserine (NLM Chemicals) / J (WoSType)},
      cin          = {INM-2 / INM-3 / INM-4 / JARA-BRAIN},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-3-20090406 /
                      I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89572},
      shelfmark    = {Neurosciences / Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20303474},
      UT           = {WOS:000279205800013},
      doi          = {10.1016/j.biopsych.2010.01.022},
      url          = {https://juser.fz-juelich.de/record/9820},
}