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000009878 0247_ $$2pmid$$apmid:19954305
000009878 0247_ $$2DOI$$a10.1089/rej.2009.0926
000009878 0247_ $$2WOS$$aWOS:000277602200019
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000009878 037__ $$aPreJuSER-9878
000009878 041__ $$aeng
000009878 082__ $$a610
000009878 084__ $$2WoS$$aGeriatrics & Gerontology
000009878 1001_ $$0P:(DE-Juel1)VDB4104$$aLiu, H.$$b0$$uFZJ
000009878 245__ $$aTransport of Alzheimer disease amyloid-beta-binding D-amino acid peptides across an in vitro blood-brain barrier model
000009878 260__ $$aLarchmont, NY$$bLiebert$$c2010
000009878 300__ $$a
000009878 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000009878 440_0 $$018202$$aRejuvenation Research$$v13$$x1549-1684$$y2
000009878 500__ $$aRecord converted from VDB: 12.11.2012
000009878 520__ $$aPreviously, two D-enantiomeric amino acid peptides, D1 and D3, which specifically bind to the amyloid-beta peptide Abeta(1-42), were identified by phage display selection. To assess the diagnostic and therapeutic potentials of D1 and D3 for the diagnosis and treatment of Alzheimer disease, the blood-brain barrier transport of these D-peptides was quantitatively evaluated in vitro. Our results showed that the apical-to-basolateral transport of D3 was more efficient than that of D1. An active efflux transport mechanism seems to oppose the transport of D1, whereas D3 is likely to be transported through the blood-brain barrier via an adsorptive-mediated transcytosis mechanism.
000009878 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems$$cP33$$x0
000009878 536__ $$0G:(DE-Juel1)FUEK505$$aBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$cP45$$x1
000009878 588__ $$aDataset connected to Web of Science, Pubmed
000009878 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000009878 650_2 $$2MeSH$$aAmyloid beta-Peptides: chemistry
000009878 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000009878 650_2 $$2MeSH$$aAnimals
000009878 650_2 $$2MeSH$$aBlood-Brain Barrier: metabolism
000009878 650_2 $$2MeSH$$aCells, Cultured
000009878 650_2 $$2MeSH$$aDose-Response Relationship, Drug
000009878 650_2 $$2MeSH$$aModels, Theoretical
000009878 650_2 $$2MeSH$$aOligopeptides: metabolism
000009878 650_2 $$2MeSH$$aOligopeptides: pharmacokinetics
000009878 650_2 $$2MeSH$$aPeptide Fragments: metabolism
000009878 650_2 $$2MeSH$$aPeptide Fragments: pharmacokinetics
000009878 650_2 $$2MeSH$$aProtein Binding
000009878 650_2 $$2MeSH$$aProtein Transport
000009878 650_2 $$2MeSH$$aRats
000009878 650_2 $$2MeSH$$aValidation Studies as Topic
000009878 650_2 $$2MeSH$$aVerapamil: pharmacokinetics
000009878 650_7 $$00$$2NLM Chemicals$$aAmyloid beta-Peptides
000009878 650_7 $$00$$2NLM Chemicals$$aD1 peptide
000009878 650_7 $$00$$2NLM Chemicals$$aD3 peptide
000009878 650_7 $$00$$2NLM Chemicals$$aOligopeptides
000009878 650_7 $$00$$2NLM Chemicals$$aPeptide Fragments
000009878 650_7 $$052-53-9$$2NLM Chemicals$$aVerapamil
000009878 650_7 $$2WoSType$$aJ
000009878 7001_ $$0P:(DE-Juel1)VDB65869$$aFunke, S. A.$$b1$$uFZJ
000009878 7001_ $$0P:(DE-Juel1)132029$$aWillbold, D.$$b2$$uFZJ
000009878 773__ $$0PERI:(DE-600)2155984-3$$a10.1089/rej.2009.0926$$gVol. 13$$q13$$tRejuvenation research$$v13$$x1549-1684$$y2010
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000009878 9131_ $$0G:(DE-Juel1)FUEK505$$bSchlüsseltechnologien$$kP45$$lBiologische Informationsverarbeitung$$vBioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung$$x1
000009878 9141_ $$y2010
000009878 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000009878 9201_ $$0I:(DE-Juel1)VDB942$$d31.12.2010$$gISB$$kISB-3$$lStrukturbiochemie$$x0
000009878 9201_ $$0I:(DE-82)080012_20140620$$gJARA$$kJARA-HPC$$lJülich Aachen Research Alliance - High-Performance Computing$$x1
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