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@ARTICLE{Liu:9878,
      author       = {Liu, H. and Funke, S. A. and Willbold, D.},
      title        = {{T}ransport of {A}lzheimer disease amyloid-beta-binding
                      {D}-amino acid peptides across an in vitro blood-brain
                      barrier model},
      journal      = {Rejuvenation research},
      volume       = {13},
      issn         = {1549-1684},
      address      = {Larchmont, NY},
      publisher    = {Liebert},
      reportid     = {PreJuSER-9878},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Previously, two D-enantiomeric amino acid peptides, D1 and
                      D3, which specifically bind to the amyloid-beta peptide
                      Abeta(1-42), were identified by phage display selection. To
                      assess the diagnostic and therapeutic potentials of D1 and
                      D3 for the diagnosis and treatment of Alzheimer disease, the
                      blood-brain barrier transport of these D-peptides was
                      quantitatively evaluated in vitro. Our results showed that
                      the apical-to-basolateral transport of D3 was more efficient
                      than that of D1. An active efflux transport mechanism seems
                      to oppose the transport of D1, whereas D3 is likely to be
                      transported through the blood-brain barrier via an
                      adsorptive-mediated transcytosis mechanism.},
      keywords     = {Alzheimer Disease: metabolism / Amyloid beta-Peptides:
                      chemistry / Amyloid beta-Peptides: metabolism / Animals /
                      Blood-Brain Barrier: metabolism / Cells, Cultured /
                      Dose-Response Relationship, Drug / Models, Theoretical /
                      Oligopeptides: metabolism / Oligopeptides: pharmacokinetics
                      / Peptide Fragments: metabolism / Peptide Fragments:
                      pharmacokinetics / Protein Binding / Protein Transport /
                      Rats / Validation Studies as Topic / Verapamil:
                      pharmacokinetics / Amyloid beta-Peptides (NLM Chemicals) /
                      D1 peptide (NLM Chemicals) / D3 peptide (NLM Chemicals) /
                      Oligopeptides (NLM Chemicals) / Peptide Fragments (NLM
                      Chemicals) / Verapamil (NLM Chemicals) / J (WoSType)},
      cin          = {ISB-3 / JARA-HPC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB942 / $I:(DE-82)080012_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems / BioSoft:
                      Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK505},
      shelfmark    = {Geriatrics $\&$ Gerontology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:19954305},
      UT           = {WOS:000277602200019},
      doi          = {10.1089/rej.2009.0926},
      url          = {https://juser.fz-juelich.de/record/9878},
}