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@ARTICLE{Becker:9906,
      author       = {Becker, J. S. and Matusch, A. and Palm, C. and Salber, D.
                      and Morton, K.A. and Becker, S.},
      title        = {{B}ioimaging of metals in brain tissue by laser ablation
                      inductively coupled plasma mass spectrometry
                      ({LA}-{ICP}-{MS}) and metallomics},
      journal      = {Metallomics},
      volume       = {2},
      issn         = {1756-5901},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {PreJuSER-9906},
      pages        = {104 - 111},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Laser ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) has been developed and established as an
                      emerging technique in the generation of quantitative images
                      of metal distributions in thin tissue sections of brain
                      samples (such as human, rat and mouse brain), with
                      applications in research related to neurodegenerative
                      disorders. A new analytical protocol is described which
                      includes sample preparation by cryo-cutting of thin tissue
                      sections and matrix-matched laboratory standards, mass
                      spectrometric measurements, data acquisition, and
                      quantitative analysis. Specific examples of the bioimaging
                      of metal distributions in normal rodent brains are provided.
                      Differences to the normal were assessed in a Parkinson's
                      disease and a stroke brain model. Furthermore, changes
                      during normal aging were studied. Powerful analytical
                      techniques are also required for the determination and
                      characterization of metal-containing proteins within a large
                      pool of proteins, e.g., after denaturing or non-denaturing
                      electrophoretic separation of proteins in one-dimensional
                      and two-dimensional gels. LA-ICP-MS can be employed to
                      detect metalloproteins in protein bands or spots separated
                      after gel electrophoresis. MALDI-MS can then be used to
                      identify specific metal-containing proteins in these bands
                      or spots. The combination of these techniques is described
                      in the second section.},
      keywords     = {Animals / Brain Chemistry / Disease Models, Animal /
                      Histocytochemistry / Humans / Lasers / Mass Spectrometry:
                      methods / Metalloproteins: analysis / Metalloproteins:
                      metabolism / Metals, Heavy: analysis / Metals, Heavy:
                      chemistry / Metals, Heavy: metabolism / Mice / Parkinson
                      Disease: metabolism / Plasma Gases: chemistry / Rats /
                      Stroke: metabolism / Metalloproteins (NLM Chemicals) /
                      Metals, Heavy (NLM Chemicals) / Plasma Gases (NLM Chemicals)
                      / J (WoSType)},
      cin          = {INM-2 / INM-1 / INM-4 / ZCH},
      ddc          = {690},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)ZCH-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Biochemistry $\&$ Molecular Biology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:21069140},
      UT           = {WOS:000274397000002},
      doi          = {10.1039/b916722f},
      url          = {https://juser.fz-juelich.de/record/9906},
}