TY  - JOUR
AU  - Bürger, Zoé
AU  - Müller, Veronika
AU  - Hoffstaedter, Felix
AU  - Habel, Ute
AU  - Gur, Ruben C.
AU  - Windischberger, Christian
AU  - Moser, Ewald
AU  - Derntl, Birgit
AU  - Kogler, Lydia
TI  - Stressor-Specific Sex Differences in Amygdala - Frontal Cortex Networks
JO  - Journal of Clinical Medicine
VL  - 12
IS  - 3
SN  - 2077-0383
CY  - Basel
PB  - MDPI
M1  - FZJ-2023-01117
SP  - 865
PY  - 2023
AB  - Females and males differ in stress reactivity, coping, and the prevalence rates of stress-related disorders. According to a neurocognitive framework of stress coping, the functional connectivity between the amygdala and frontal regions (including the dorsolateral prefrontal cortex (dlPFC), ventral anterior cingulate cortex (vACC), and medial prefrontal cortex (mPFC)) plays a key role in how people deal with stress. In the current study, we investigated the effects of sex and stressor type in a within-subject counterbalanced design on the resting-state functional connectivity (rsFC) of the amygdala and these frontal regions in 77 healthy participants (40 females). Both stressor types led to changes in subjective ratings, with decreasing positive affect and increasing negative affect and anger. Females showed higher amygdala-vACC and amygdala-mPFC rsFC for social exclusion than for achievement stress, and compared to males. Whereas a higher amygdala-vACC rsFC indicates the activation of emotion processing and coping, a higher amygdala-mPFC rsFC indicates feelings of reward and social gain, highlighting the positive effects of social affiliation. Thus, for females, feeling socially affiliated might be more fundamental than for males. Our data indicate interactions of sex and stressor in amygdala-frontal coupling, which translationally contributes to a better understanding of the sex differences in prevalence rates and stress coping.
LB  - PUB:(DE-HGF)16
C6  - 36769521
UR  - <Go to ISI:>//WOS:000930153400001
DO  - DOI:10.3390/jcm12030865
UR  - https://juser.fz-juelich.de/record/996117
ER  -