TY  - JOUR
AU  - Rezaei-Ghaleh, Nasrollah
AU  - Agudo-Canalejo, Jaime
AU  - Griesinger, Christian
AU  - Golestanian, Ramin
TI  - Response to Comment on “Following Molecular Mobility during Chemical Reactions: No Evidence for Active Propulsion” and “Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question”
JO  - Journal of the American Chemical Society
VL  - 144
IS  - 30
SN  - 0002-7863
CY  - Washington, DC
PB  - ACS Publications
M1  - FZJ-2023-01123
SP  - 13441 - 13445
PY  - 2022
AB  - In their Comment (DOI: 10.1021/jacs.2c02965) on two related publications by our group (J. Am. Chem. Soc. 2022,144, 1380−1388; DOI: 10.1021/jacs.1c11754) and another (J. Am. Chem. Soc. 2021, 143, 20884−20890; DOI: 10.1021/jacs.1c09455), Huang and Granick refer to the diffusion NMR measurements of molecules during a copper-catalyzed azide−alkyne cycloaddition (CuAAC) “click” reaction. Here we respond to their comments and maintain that no measurable diffusion enhancement was observed during the reaction. We expand on the physical arguments presented in our original JACS Article regarding the appropriate reference state for the diffusion coefficient and present new data showing that the use of other reference states, as suggested by Huang and Granick, will still support our conclusion that the two reactants and one product of the CuAAC reaction do not exhibit boosted mobility during the reaction.
LB  - PUB:(DE-HGF)16
C6  - 35919985
UR  - <Go to ISI:>//WOS:000835696600001
DO  - DOI:10.1021/jacs.2c02850
UR  - https://juser.fz-juelich.de/record/996126
ER  -