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000996736 1001_ $$0P:(DE-Juel1)194492$$aRezaei-Ghaleh, Nasrollah$$b0$$eCorresponding author
000996736 245__ $$aFamilial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates
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000996736 520__ $$aAmyloid-beta (Aβ) deposition as senile plaques is a pathological hallmark of Alzheimer's disease (AD). AD is characterized by a large level of heterogeneity in amyloid pathology, whose molecular origin is poorly understood. Here, we employ NMR spectroscopy and MD simulation at ambient and high pressures and investigate how AD-related mutations in Aβ peptide influence the stability of Aβ aggregates. The pressure-induced monomer dissociation from Aβ aggregates monitored by NMR demonstrated that the Iowa (D23N), Arctic (E22G), and Osaka (ΔE22) mutations altered the pressure stability of Aβ40 aggregates in distinct manners. While the NMR data of monomeric Aβ40 showed only small localized effects of mutations, the MD simulation of mutated Aβ fibrils revealed their distinct susceptibility to elevated pressure. Our data propose a structural basis for the distinct stability of various Aβ fibrils and highlights "stability" as a molecular property potentially contributing to the large heterogeneity of amyloid pathology in AD.
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000996736 7001_ $$00000-0001-8319-1030$$aAmininasab, Mehriar$$b1
000996736 7001_ $$0P:(DE-HGF)0$$aGiller, Karin$$b2
000996736 7001_ $$0P:(DE-HGF)0$$aBecker, Stefan$$b3
000996736 773__ $$0PERI:(DE-600)2522838-9$$a10.1021/acs.jpclett.2c03729$$gp. 1427 - 1435$$p1427 - 1435$$tThe journal of physical chemistry letters$$v14$$x1948-7185$$y2023
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