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@ARTICLE{Kleineberg:999178,
      author       = {Kleineberg, Nina N. and Schmidt, Claudia C. and Richter,
                      Monika K. and Bolte, Katharina and Schloss, Natalie and
                      Fink, Gereon R. and Weiss-Blankenhorn, Peter},
      title        = {{G}esture meaning modulates the neural correlates of
                      effector-specific imitation deficits in left hemisphere
                      stroke},
      journal      = {NeuroImage: Clinical},
      volume       = {37},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2023-01212},
      pages        = {103331 -},
      year         = {2023},
      abstract     = {BackgroundPrevious studies on left hemisphere (LH) stroke
                      patients reported effector-specific (hand, fingers,
                      bucco-facial) differences in imitation performance.
                      Furthermore, imitation performance differed between
                      meaningless (ML) and meaningful (MF) gestures. Recent work
                      suggests that a gesture’s meaning impacts the body-part
                      specificity of gesture imitation.MethodsWe tested the
                      hypothesis that the gesture’s meaning (ML vs MF) affects
                      the lesion correlates of effector-specific imitation
                      deficits (here: bucco-facial vs arm/hand gestures) using
                      behavioural data and support vector regression-based
                      lesion-symptom mapping (SVR-LSM) in a large sample of 194
                      sub-acute LH stroke patients.ResultsBehavioural data
                      revealed a significant interaction between the effector used
                      for imitation and the meaning of the imitated gesture.
                      SVR-LSM analyses revealed shared lesion correlates for
                      impaired imitation independent of effector or gesture
                      meaning in the left supramarginal (SMG) and superior
                      temporal gyri (STG). Besides, within the territory of the
                      left middle cerebral artery, impaired imitation of
                      bucco-facial gestures was associated with more anterior
                      lesions, while arm/hand imitation deficits were associated
                      with more posterior lesions. MF gestures were specifically
                      associated with lesions in the left inferior frontal gyrus
                      and the left insular region. Notably, an interaction of
                      effector-specificity and gesture meaning was also present at
                      the lesion level: A more pronounced difference in imitation
                      performance between the effectors for ML (versus MF)
                      gestures was associated with left-hemispheric lesions in the
                      STG, SMG, putamen, precentral gyrus and white matter
                      tracts.ConclusionThe current behavioural data show that ML
                      gestures are particularly sensitive in assessing
                      effector-specific imitation deficits in LH stroke patients.
                      Moreover, a gesture’s meaning modulated the
                      effector-specific lesion correlates of bucco-facial and
                      arm/hand gesture imitation. Hence, it is crucial to consider
                      gesture meaning in apraxia assessments.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / DFG
                      project 431549029 - SFB 1451: Schlüsselmechanismen normaler
                      und krankheitsbedingt gestörter motorischer Kontrolle
                      (431549029)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36716655},
      UT           = {WOS:000976721800001},
      doi          = {10.1016/j.nicl.2023.103331},
      url          = {https://juser.fz-juelich.de/record/999178},
}