TY  - JOUR
AU  - Bajaj, Sahil
AU  - Blair, Karina S.
AU  - Dobbertin, Matthew
AU  - Patil, Kaustubh R.
AU  - Tyler, Patrick M.
AU  - Ringle, Jay L.
AU  - Bashford-Largo, Johannah
AU  - Mathur, Avantika
AU  - Elowsky, Jaimie
AU  - Dominguez, Ahria
AU  - Schmaal, Lianne
AU  - Blair, R. James R.
TI  - Machine learning based identification of structural brain alterations underlying suicide risk in adolescents
JO  - Discover mental health
VL  - 3
IS  - 1
SN  - 2731-4383
CY  - [Cham]
PB  - Springer International Publishing
M1  - FZJ-2023-01219
SP  - 6
PY  - 2023
AB  - Suicide is the third leading cause of death for individuals between 15 and 19 years of age. The high suicide mortality rate and limited prior success in identifying neuroimaging biomarkers indicate that it is crucial to improve the accuracy of clinical neural signatures underlying suicide risk. The current study implements machine-learning (ML) algorithms to examine structural brain alterations in adolescents that can discriminate individuals with suicide risk from typically developing (TD) adolescents at the individual level. Structural MRI data were collected from 79 adolescents who demonstrated clinical levels of suicide risk and 79 demographically matched TD adolescents. Region-specific cortical/subcortical volume (CV/SCV) was evaluated following whole-brain parcellation into 1000 cortical and 12 subcortical regions. CV/SCV parameters were used as inputs for feature selection and three ML algorithms (i.e., support vector machine [SVM], K-nearest neighbors, and ensemble) to classify adolescents at suicide risk from TD adolescents. The highest classification accuracy of 74.79% (with sensitivity = 75.90%, specificity = 74.07%, and area under the receiver operating characteristic curve = 87.18%) was obtained for CV/SCV data using the SVM classifier. Identified bilateral regions that contributed to the classification mainly included reduced CV within the frontal and temporal cortices but increased volume within the cuneus/precuneus for adolescents at suicide risk relative to TD adolescents. The current data demonstrate an unbiased region-specific ML framework to effectively assess the structural biomarkers of suicide risk. Future studies with larger sample sizes and the inclusion of clinical controls and independent validation data sets are needed to confirm our findings.
LB  - PUB:(DE-HGF)16
C6  - 37861863
UR  - <Go to ISI:>//WOS:001319058800001
DO  - DOI:10.1007/s44192-023-00033-6
UR  - https://juser.fz-juelich.de/record/999190
ER  -