BackgroundAmino acid PET using the tracer O-(2-[18F]fluoroethyl)-l-tyrosine (FET) is one of the most reliable imaging methods for detecting glioma recurrence. Here, we hypothesized that functional MR connectivity between the metabolic active recurrent tumor region and resting-state networks of the brain could serve as a prognostic imaging biomarker for overall survival (OS).MethodsThe study included 82 patients (26–81 years; median Eastern Cooperative Oncology Group performance score, 0) with recurrent gliomas following therapy (WHO-CNS 2021 grade 4 glioblastoma, n = 57; grade 3 or 4 astrocytoma, n = 12; grade 2 or 3 oligodendroglioma, n = 13) diagnosed by FET PET simultaneously acquired with functional resting-state MR. [...]

BACKGROUNDGlioma patients frequently suffer from cognitive dysfunction potentially related to brain damage caused by tumor invasion or therapeutic intervention. We hypothesized that, as in other neurological disorders, the long-term outcome of cognitive functions in glioma patients critically depends on maintaining the structural connectivity of multiple interconnected networks.PATIENTS AND METHODSOne hundred and twenty-one glioma patients (median age, 52 years; median ECOG score, 1) with histomolecularly characterized CNS WHO grade 3 or 4 gliomas were investigated after a median time of 14 months (range, 1-214 months) following first-line therapy, including resection and chemoradiation with alkylating agents. [...]

AbstractBackground. In glioma patients, tumor growth and subsequent treatments are associated with various types ofbrain lesions. [...]

PET imaging using radiolabeled amino acids in addition to MRI has become a valuable diagnostic tool in the clinical management of patients with brain tumors. This review provides a comprehensive overview of PET studies in glioma patients with a mutation in the isocitrate dehydrogenase gene (IDH). [...]

PET using radiolabelled amino acids has become an essential tool for diagnosing brain tumours in addition to MRI. O-(2-[18F]fluoroethyl)-L-tyrosine (FET) is one of the most successful tracers in the field [...]