Zusammenfassungen

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BACKGROUNDIn glioma patients, tumor development and multimodality therapy are associated with changes in health-related quality of life (HRQoL). It is largely unknown how different types and locations of tumor- and treatment-related brain lesions, as well as their relationship to white matter tracts and functional brain networks, affect HRQoL.MATERIAL AND METHODSIn 121 patients with pretreated gliomas of WHO CNS grades 3 or 4, structural MRI, O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET, resting-state functional MRI (rs-fMRI) and self-reported HRQoL questionnaires (EORTC QLQ-C30/BN20) were obtained. [...]

BACKGROUNDGlioma patients frequently suffer from cognitive dysfunction potentially related to brain damage caused by tumor invasion or therapeutic intervention. We hypothesized that, as in other neurological disorders, the long-term outcome of cognitive functions in glioma patients critically depends on maintaining the structural connectivity of multiple interconnected networks.PATIENTS AND METHODSOne hundred and twenty-one glioma patients (median age, 52 years; median ECOG score, 1) with histomolecularly characterized CNS WHO grade 3 or 4 gliomas were investigated after a median time of 14 months (range, 1-214 months) following first-line therapy, including resection and chemoradiation with alkylating agents. [...]

BACKGROUNDGlioma patients frequently suffer from cognitive dysfunction potentially caused by tumor invasion or treatment effects. We hypothesized that cognitive functioning in pretreated glioma patients critically depends on the maintained structural connectivity of multiple brain networks. [...]

Peptides that can form large, stable pores at acidic pH values are of direct interest to deliver cargo to cells and cell compartments with acidic pH. Peptides of the pHD (pH-dependent delivery peptides) have the unique property of forming stable pores with diameters of ∼30–-100 Å at pH below ∼6. [...]

Katanin, a microtubule-severing enzyme, plays a pivotal role in regulating cytoskeletal dynamics, cell division, and intracellular transport. Katanin does this by forming a hexamer and undergoing a conformational change from its open “spiral” to closed “ring” state, which enacts mechanical forces required for the removal of tubulin dimers from the microtubule lattice. [...]

The availability of well performing and cost efficient energy storage devices is of utmost importance for a smooth transition to sustainable energy. Lithium-ion batteries (LIBs) have been successfully commercialized and widely used in various portable devices. [...]

Flooding and dehydration reduce stability and power performance in Proton Exchange Membrane Fuel Cells (PEMFCs). The Gas Diffusion Layer (GDL) plays a crucial role in facilitating reactant gas transport and removing product water from the electrode. [...]

BackgroundSome individuals seem less susceptible to the effect of high white matter hyperintensity (WMH) load on cognition reflecting differences in individual cognitive reserve (CR). Little is known about young- or middle-aged participants. [...]