Open Access

Parkinson’s disease (PD) exhibits high heterogeneity in disease progression, complicating management and increasing required sample sizes for clinical trials. This study evaluates Brain Age Gap (BAG)—the difference between brain age and chronological age—for predicting disease progression in PD. [...]

Steigende Verkehrsaufkommen im Personen- und Güterverkehr stellen den deutschen Straßenverkehr neben der Erreichung der Treibhausgasneutralität vor zwei zentrale Herausforderungen. Einerseits muss die Verkehrsinfrastruktur so ausgelegt werden, dass zukünftige Verkehrsströme bewältigt werden können. [...]

The geometric eigenmodes, derived from the shape of the cortical surface, have been suggested as a better model for explaining brain function due to their high accuracy in reconstructing patterns of both spontaneous and stimulus-evoked brain activity patterns captured by functional MRI, when contrasted with alternative models including structural connectome derived bases. While a descriptive representation offers valuable utility for neuroimaging studies, it is necessary to examine the extent to which it supports a mechanistic explanation for human brain function. [...]

Improving solid electrolytes is critical for high-performance all-solid-state batteries, yet the microstructural features that enable fast ion transport remain poorly understood. Here, we use multiscale modeling to resolve polycrystalline ion transport from atomic-scale hopping at grain boundaries to continuum-scale percolation, thereby providing insights into realistic solid-electrolyte microstructures. [...]

The lack of energy balance closure in Eddy- Covariance (EC) measurements is a well-known, still unresolved challenge in mi-crometeorology, with energy balance closure (EBC) rates typically ranging between 60% and 80%. While numerous hypotheseshave been proposed to explain this imbalance, the relative contributions of neglected energy storage terms, data quality and fluxprocessing options remain insufficiently disentangled. [...]