Open Access

A missense variant in SLC1A3, which results in a proline to arginine substitution in the glial excitatory amino acid transporter 1 (EAAT1), causes a severe form of episodic ataxia type 6, characterized by recurrent attacks of ataxia and epilepsy. EAATs are dual function transport proteins, and the P290R variant reduces secondary active glutamate transport rates, while enhancing the anion channel activity. [...]

Soil water flow, particularly preferential flow (PF), is a critical control on hydrological and biogeochemical processes, including groundwater recharge, contaminant transport, and carbon cycling. However, it remains challenging to predict PF occurrence across large environmental gradients. [...]

Repeated droughts in recent years and their impacts on managed and natural ecosystems have stressed the need for seasonal forecasts of subsurface water resources, including their depletion and their recovery. To address this need, we provide an experimental water resources bulletin with a 7-months forecast of the subsurface water storage anomaly from the surface to 60m depth at the beginning of each meteorological season. [...]