Open Access

Adverse childhood experiences (ACE) contribute significantly to mental disorders. While existing research has primarily focused on specific diagnostic categories, a comprehensive understanding of how childhood trauma interacts with biological factors, symptom severity and functioning requires a broader perspective. [...]

Sleep appears to modulate brain-wide neurofluid transport, encompassing the movement and exchange of cerebrospinal and interstitial fluids via perivascular pathways. However, neurofluid transport in common sleep disorders, such as insomnia disorder and obstructive sleep apnea, requires further assessment. [...]