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Two stacks of thin Zr foils were irradiated with 30 and 50 MeV deuterons, respectively, using the Lawrence Berkeley National Laboratory 88-Inch Cyclotron, and 19 excitation functions for natZr(d,x) reactions were measured over a beam energy range of 6.3–47.64 MeV, where the independent cross sections for natZr(d,x)88Nb and natZr(d,x)86m,gY were measured for the first time. The well-characterized natFe(d,x)56Co, natNi(d,x)56Co, natNi(d,x)58Co, natNi(d,x)61Cu, natTi(d,x)46Sc and natTi(d,x)48V monitor reactions were used to determine the deuteron beam current throughout the stacks. [...]

The development of the functional cortical hierarchy, spanning sensorimotor to association systems, is exclusively studied as a function of age. During adolescence, this overlooks puberty as a major neurodevelopmental driver and source of variability. [...]

Introduction: Age-related declines in cognitive and motor functions show highly variable trajectories. To better understand the underlying mechanisms, we investigated multivariate associative effects between modifiable vascular risk factors, biological brain aging, cognitive, and motor performance in 40,579 individuals from the population-based UK Biobank and Hamburg City Health Study.Methods: We employed partial least squares correlation analysis (PLS) to model associations between multi-domain cognitive and motor test scores and three distinct MRI-derived markers of biological brain aging: relative brain age (from morphometric brain imaging), white matter hyperintensity load, and peak width of skeletonized mean diffusivity. [...]

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Background: Friedreich ataxia is a debilitating multisystem neurodegenerative disorder. Depression is more prevalent in individuals with Friedreich ataxia (14%-36%) than in the general European population (8.5%). [...]