2025-09-17 10:39 |
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2025-09-16 20:54 |
[FZJ-2025-03758]
Journal Article
Hesse, R. ; Gertzen, C. G. W. ; Schmuck, J. F. ; et al
The coming of age of DNA‐based catalysts for therapeutic applications
DNA enzymes, also known as DNAzymes (Dz), are synthetic high-precision biocatalysts that have been identified by in vitro selection three decades ago.1 Dz are usually short, single-stranded DNA molecules that catalyse chemical reactions through their specific three-dimensional structure.2 Due to their enormous therapeutic potential, particular interest has been invested in RNA-cleaving Dz, such as the 8–17 Dz and 10–23 Dz2. In general, these DNAzymes share a modular architecture comprising a (conserved) catalytic loop sequence and adaptable substrate binding arm sequences that, following specific design guidelines, can be modified to bind virtually any given target RNA with high selectivity..
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2025-09-16 15:03 |
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2025-09-12 13:47 |
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2025-09-11 11:48 |
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2025-09-08 13:47 |
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2025-09-08 13:32 |
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2025-09-08 13:25 |
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2025-09-05 09:07 |
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2025-09-03 13:30 |
[FZJ-2025-03645]
Journal Article
Liu, W. ; Küppers, V. ; Tahmasian, M.
Brain signature of sleep quality
Healthy sleep is a fundamental pillar of various neurophysio-logical, emotional, and cognitive processes, including emotionregulation, memory consolidation, and brain waste clearance [1–3]. Sleep quality is a multidimensional concept that has beenwidely assessed using the Pittsburgh Sleep Quality Index (PSQI)[4, 5]. [...]
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