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Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis sativa, has gained significant attention due to its diverse therapeutic properties, including anti-inflammatory, antioxidant, and anxiolytic effects. However, its clinical application is hindered by poor water solubility, which limits its bioavailability. [...]

Neuropsychiatric disorders show shared and distinct neurobiological correlates. A cross-disorder genome-wide association study (GWAS) identified 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that were associated with at least four neuropsychiatric disorders, and 22 SNPs that were associated predominantly with schizophrenia. [...]

The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). [...]

Posttranslational modifications of Y-box binding protein (YB)-1 are the prerequisite for its very different protein functions. Here, we investigate the underlying molecular mechanisms of YB-1 guanidinylation and link increased serum urea levels as well as the activity of glycine amidinotransferase (GATM) with guanidinylation [...]

Recent technological and methodological advances have facilitated the implementation and standardization of functional magnetic resonance imaging (fMRI) studies in rodents. Integration of such fMRI data with maps coding for the cyto- and receptor architectonic organization of the brain, as well as of its structural connectivity patterns, will facilitate the advance of our understanding of the biological underpinnings of functional networks and accelerate translational research using rat models. [...]