Dissertation / PhD Thesis/Book

PreJuSER-12576

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Metabolische 13C-Stoffflussanalyse - vom isotopisch stationären zum instationären Fall

Grönke, K. (Corresponding author)FZJ*

2010
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag Jülich
ISBN: 978-3-89336-713-9

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Please use a persistent id in citations: http://hdl.handle.net/2128/15191

Abstract: With the established tools of $^{13}$C-Metabolic Flux Analysis (MFA) up to now it is not possible to analyse the metabolism of microorganisms in biotechnological production processes because of the long labelling time. Due to the proceeding development in mass spectrometry it is now possible to measure the $^{13}$C-labelling directly in the intracellular metabolites of the central metabolism (glycolysis, pentose-phosphate-pathway and citric acid cycle). Here it is assumed that an isotopic steady state will be reached in a much shorter time. Main objective of this work was to use this data and reduce the labelling time to make it possible to analyse the cell metabolism in production processes that are mainly batch and fed batch processes. [...]

Note: Record converted from VDB: 12.11.2012
Note: Universität Siegen, Diss., 2010

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Contributing Institute(s):

1. Biotechnologie 2 (IBT-2)

Research Program(s):

1. Biotechnologie (PBT)

Appears in the scientific report 2010

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Database coverage:

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