Open Access

Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate N-methyl-D-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline. ALX5407 is a potent and selective inhibitor of GlyT1 derived from the metabolic intermediate sarcosine (N-methylglycine) that showed antipsychotic potential in a number of animal models. [...]

This work studies a computation in-memory concept for binary multiply-accumulate operations based on complementary resistive switches (CRS). By exploiting the in-memory boolean exclusive OR (XOR) operation of single CRS devices, the Hamming Distance (HD) can be calculated if the center electrodes of multiple CRS cells are connected. [...]

6-L-[18F]Fluoro-m-tyrosine (6-L-[18F]FMT) represents a valuable alternative to 6-L-[18F]FDOPA which is conventionally used for the diagnosis and staging of Parkinson’s disease. However, clinicalapplications of 6-L-[18F]FMT have been limited by the paucity of practical production methods for its automated production. [...]

Redox-based random-access memory (ReRAM) has the potential to successfully address the technological barriers that today’s memory technologies face. One of its promising features is its fast switching speed down to 50 ps. [...]

Tungsten is an outstanding material and due to its properties like highest melting point and tensile strength of all natural metals and its high thermal conductivity it is a prime candidate for being used in very harsh environments and for challenging applications like X-ray tubes or as plasma facing material (PFM) in fusion reactors. Unfortunately, high brittle to ductile transition temperature and hardness represent a great challenge for classic manufacturing processes. [...]

Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. [...]

The study of oxide electrocatalysts is often complicated by the formation of complex and unknown surface species as well as the interaction between the catalysts and common support materials. Because unknown surface species may result from air exposure, we developed a clean transfer system for the air-free electrochemical investigation of epitaxial thin films fabricated under typical surface science conditions. [...]

Ornamental heather (Calluna vulgaris) production is characterized by high risks such as occurrence of fungal diseases and plant losses. Given the general absence of formal research on this economically important production system, farmers depend on their own approaches to assess plant vitality. [...]

Skyrmions are vortex-like spin textures that form strings in magnetic crystals. Due to the analogy to elastic strings, skyrmion strings are naturally expected to braid and form complex three-dimensional patterns, but this phenomenon has not been explored yet. [...]

The cue-reactivity paradigm is a widely adopted neuroimaging probe engendering brain activity linked with attentional, affective, and reward processes following presentation of appetitive stimuli. Given the multiple mental operations invoked, we sought to decompose cue-related brain activity into constituent components employing emergent meta-analytic techniques when considering drug and natural reward-related cues. [...]