Open Access

The voltage-gated calcium channel CaV2.2 is predominantly located in neuronal synapses, where it plays a role in pain signaling and neurotransmitter release. Furthermore, CaV2.2 is important during early central nervous system development, as it is subsequently replaced by other calcium channels. [...]

Background: Amyloid transthyretin cardiomyopathy (ATT R-CM) results from extracellular deposition of misfolded transthyretin (TT R), causing progressive heart failure. Naturally-occurring antibodies (nAbs) targeting misfolded proteins exist in neurodegenerative disease, but their presence in ATT R-CM is unknown. [...]

High-quality crystalline growth of a thin film on sapphire requires sufficient substrate preparation,often achieved via aggressive chemical cleaning. Direct thermal reconstruction of the sapphire sub-strate via a CO2 laser beam may provide an alternative method to prepare the substrate for epitaxywithout the use of any chemical processing. [...]

Recent advances in group-IV materials, particularly germanium–tin (GeSn) alloys, have reinvigorated the pursuit of CMOS-compatible light sources. The optical performance of GeSn is governed by the coupled effects of Sn composition and lattice strain, which together dictate optical gain and the maximum operating temperature. [...]