Zeitschriftenaufsätze

BackgroundSchizophrenia (SCZ) and bipolar disorder (BD) are severe psychotic disorders with overlapping clinical manifestations, leading to high rates of misdiagnosis. This study aims to identify disorder-specific neurophysiological biomarkers using electroencephalography and contrastive machine learning to improve differential diagnosis.MethodsResting-state electroencephalography was recorded from 52 patients with BD, 65 with SCZ, and 75 healthy controls. [...]

BackgroundMental disorders show pronounced phenotypic heterogeneity within diagnoses and overlap across them, limiting the ability of group-level studies to identify distinct brain correlates. Large, transdiagnostic samples and individualized approaches are therefore needed to reveal systematic patterns that underlie variability and overlap in psychiatric brain alterations.MethodsIn a global collaborative effort, we analyzed region-wise, in vivo cortical thickness (CT) estimates from 10,188 patients (schizophrenia, generalized anxiety, autism spectrum, bipolar, obsessive-compulsive, and major depressive disorders) and 12,251 controls (5-80 years old) [...]

Understanding functional connectivity alterations across manic, depressive, and remitted states of bipolar disorder (BD) remains an important challenge. In this cross-sectional study, we collected resting-state functional magnetic resonance imaging data from 117 BD patients, including manic BD patients (BipM: n = 38), depressive BD patients (BipD: n = 42), remitted BD patients (rBD: n = 37), and 35 healthy controls. [...]

Background: Fatigue is a prevalent and debilitating symptom among cancer patients (pts), yet routine assessment still relies on self-report instruments such as the FACIT-Fatigue (FACIT-F). To support continuous fatigue monitoring, we developed a wearable-derived Machine Learning Fatigue Score (ML-F; range 0–52, aligned with FACIT-F) in an observational study (72 pts, 22 healthy controls; 8 weeks), combining 35 physiological features from a fitness tracker (e.g., heart rate- and respiration-related measures) and anchoring the score to a single baseline FACIT-F assessment.Research Question: This study reports the initial clinical validation of the ML-F.Methods: Data were pooled from two prospective cohorts: (1) observational cohort and (2) an app-based feasibility study (38 pts; 4 weeks). [...]