Zeitschriftenaufsätze

C–N axially chiral carbazole derivatives were synthesised by an intramolecular Buchwald–Hartwig amination starting from C–C axially chiral biaryls utilising an axial-to-axial chirality transfer with enantiospecificities up to 91%. The mechanism of the chirality transfer was investigated via DFT calculations..

Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis sativa, has gained significant attention due to its diverse therapeutic properties, including anti-inflammatory, antioxidant, and anxiolytic effects. However, its clinical application is hindered by poor water solubility, which limits its bioavailability. [...]

Neuropsychiatric disorders show shared and distinct neurobiological correlates. A cross-disorder genome-wide association study (GWAS) identified 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that were associated with at least four neuropsychiatric disorders, and 22 SNPs that were associated predominantly with schizophrenia. [...]

The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). [...]

Posttranslational modifications of Y-box binding protein (YB)-1 are the prerequisite for its very different protein functions. Here, we investigate the underlying molecular mechanisms of YB-1 guanidinylation and link increased serum urea levels as well as the activity of glycine amidinotransferase (GATM) with guanidinylation [...]