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2025-07-10
14:51

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2025-07-09
14:22
[FZJ-2025-03016] Journal Article
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Asymmetric synthesis of C–N axially chiral carbazoles via axial-to-axial chirality transfer
C–N axially chiral carbazole derivatives were synthesised by an intramolecular Buchwald–Hartwig amination starting from C–C axially chiral biaryls utilising an axial-to-axial chirality transfer with enantiospecificities up to 91%. The mechanism of the chirality transfer was investigated via DFT calculations..

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2025-07-09
14:13
[FZJ-2025-03014] Journal Article
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Water modulated influence of intramolecular hydrogen-bonding on the conformational properties of Cannabidiol (CBD)
Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis sativa, has gained significant attention due to its diverse therapeutic properties, including anti-inflammatory, antioxidant, and anxiolytic effects. However, its clinical application is hindered by poor water solubility, which limits its bioavailability. [...]

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2025-07-09
09:55
DBCoverage [FZJ-2025-03013] Journal Article
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Neurobiological correlates of schizophrenia-specific and highly pleiotropic genetic risk scores for neuropsychiatric disorders.
Translational Psychiatry 15(1), - ()
Neuropsychiatric disorders show shared and distinct neurobiological correlates. A cross-disorder genome-wide association study (GWAS) identified 23 highly pleiotropic single-nucleotide polymorphisms (SNPs) that were associated with at least four neuropsychiatric disorders, and 22 SNPs that were associated predominantly with schizophrenia. [...]
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2025-07-08
14:04

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2025-07-08
13:47
DBCoverage [FZJ-2025-03009] Journal Article
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Novel dietary herbal preparations with inhibitory activities against multiple SARS-CoV-2 targets: A multidisciplinary investigation into antiviral activities
The outbreak of the COVID-19 pandemic has resulted in not <7.1million deaths globally as of December 2024. Many new variants of concern have continued to emerge since the initial outbreak of the original SARS-CoV-2 virus traceable to the Wuhan strain (Wuhan-Hu-1). [...]

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2025-07-08
13:33
[FZJ-2025-03008] Journal Article
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Guanidinylation of the cold shock protein YB ‐1: Molecular basis, structural changes and Notch‐3 receptor binding
Protein science 34(7), e70188 () [10.1002/pro.70188]
Posttranslational modifications of Y-box binding protein (YB)-1 are the prerequisite for its very different protein functions. Here, we investigate the underlying molecular mechanisms of YB-1 guanidinylation and link increased serum urea levels as well as the activity of glycine amidinotransferase (GATM) with guanidinylation [...]

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2025-07-08
13:08

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2025-07-08
13:06

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2025-07-08
12:52

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