Zeitschriftenaufsätze

Patients with schizophrenia frequently suffer from motor abnormalities, but underlying alterations in neuroarchitecture remain unclear. Here, we aimed to disentangle dyskinesia from parkinsonism in motor structures of patients with schizophrenia and to assess associated molecular architecture. [...]

The study of associations between inter-individual differences in brain structure and behaviour has a long history in psychology and neuroscience. Many associations between psychometric data, particularly intelligence and personality measures and local variations of brain structure have been reported. [...]

Most lncRNAs display species-specific expression patterns suggesting that animal models of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and oncogenic pathways in humans. Among these pathways, Sonic Hedgehog (SHH) signaling is aberrantly activated in several human cancer entities. [...]

Intrinsically disordered proteins (IDPs) do not fold into a unique three-dimensional structure but sample differentconfigurations of different probabilities that further change with the surrounding of the IDPs. The structuralheterogeneity and dynamics of IDPs pose a challenge for the characterization of their structures by experimentaltechniques only. [...]

Simulating the process of amyloid aggregation with atomic detail is a challenging task for various reasons.One of them is that it is difficult to parametrise a force field such that all protein states ranging from thefolded through the unfolded to the aggregated state are represented with the same level of accuracy.Here, we test whether the consideration of electronic polarisability improves the description of thedifferent states of Ab16–22. Surprisingly, the CHARMM Drude polarisable force field is found to performworse than its unpolarisable counterpart CHARMM36m. [...]

The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of IAPP aggregation and being the target of IAPP toxicity. [...]

Sickle cell disease is a hemoglobinopathy resulting from a point mutation from glutamateto valine at position six of the β-globin chains of hemoglobin. This mutation givesrise to pathological aggregation of the sickle hemoglobin and, as a result, impaired oxygenbinding, misshapen and short-lived erythrocytes, and anemia. [...]

The motion of pedestrians is subject to a wide range of influences and exhibits a rich phenomenology. To enable precise measurement of the density and velocity we use an alternative definition using Voronoi diagrams which exhibits smaller fluctuations than the standard definitions. [...]

The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug development of Alzheimer’s disease (AD). AD mouse models that develop Aβ pathology have been used to demonstrate in vivo efficacy of compounds that later failed in clinical development. [...]