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2024-02-22
16:28

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2024-02-22
13:38
DBCoverage [FZJ-2024-01731] Journal Article
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High‐Bandgap Perovskites for Efficient Indoor Light Harvesting
The use of metal-halide perovskites in photovoltaic applications has become increasingly attractive due to their low-temperature manufacturing processes and long charge-carrier lifetimes. High-bandgap perovskite solar cells have potential for indoor applications due to their efficient absorption of the spectrum of light-emitting diodes (LEDs). [...]
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2024-02-22
07:53

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2024-02-16
08:30
[FZJ-2024-01653] Journal Article
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An orally available Ca v 2.2 calcium channel inhibitor for the treatment of neuropathic pain
British journal of pharmacology 2024;1-23, bph.16309 () [10.1111/bph.16309]
AbstractBackground and Purpose:Neuropathic pain affects up to 10% of the global popula-tion and is caused by an injury or a disease affecting the somatosensory, peripheral,or central nervous system. NP is characterized by chronic, severe and opioid-resistantproperties. [...]

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2024-02-16
08:23

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2024-02-16
08:21
[FZJ-2024-01648] Journal Article
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Channelrhodopsin‐2 Oligomerization in Cell Membrane Revealed by Photo‐Activated Localization Microscopy
Angewandte Chemie 2024, e202307555 () [10.1002/anie.202307555]
Microbialrhodopsinsare retinalmembraneproteinsthat founda broadapplicationin optogenetics.Theoligomericstate of rhodopsinsis importantfor their functionalityand stability.Of particularinterestis the oligomericstate in the cellularnativemembraneenvironment.Fluorescencemicroscopyprovidespowerfultools to determinetheoligomericstate of membraneproteinsdirectlyin cells. Amongthese methodsis quantitativephotoactivatedlocalizationmicroscopy(qPALM)allowingthe investigationof molecularorganizationat the level of singleproteinclusters.Here,we applyqPALMto investigatethe oligomericstate of the first and most used optogenetictool Channelrhodopsin-2(ChR2)in the plasmamembraneof eukaryoticcells. [...]

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2024-02-14
10:10
[FZJ-2024-01603] Journal Article
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Conserved Signal Transduction Mechanisms and Dark Recovery Kinetic Tuning in the Pseudomonadaceae Short Light, Oxygen, Voltage (LOV) Protein Family
Light-Oxygen-Voltage (LOV) flavoproteins transduce a light signal into variable signaling outputs via a structural rearrangement in the sensory core domain, which is then relayed to fused effector domains via α-helical linker elements. Short LOV proteins from Pseudomonadaceae consist of a LOV sensory core and N- and C-terminal α-helices of variable length, providing a simple model system to study the molecular mechanism of allosteric activation [...]

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2024-02-14
07:08

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2024-02-12
12:33

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2024-02-12
12:29

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