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Much effort has been spent clustering neurons into transcriptomic or functional cell types and characterizingthe differences between them. Beyond subdividing neurons into categories, we must recognize that no twoneurons are identical and that graded physiological or transcriptomic properties exist within cells of agiven type. [...]

Optineurin is an autophagy receptor that plays an important role in the selective degradation of mitochondria, protein aggregates, and intracellular pathogens. It recognizes ubiquitylated cargo by its ubiquitin-binding in ABIN and NEMO (UBAN) domain and recruits the autophagic machinery through its LC3-interacting region (LIR) domain. [...]

Functional connectivity (FC) gradients derived from fMRI provide valuable insights into individual differences in brain organisation, yet aligning these gradients across individuals poses challenges for meaningful group comparisons. Procrustes alignment is often employed to standardize gradients, but the choice of the number of gradients used in alignment introduces complexities that may affect the validity of individual-level analyses. [...]