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2021-07-27
17:59
[FZJ-2021-03099] Journal Article
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The evolution of Materials Acceleration Platforms: toward the laboratory of the future with AMANDA
The development of complex functional materials poses a multi-objective optimization problem in a large multi-dimensional parameter space. Solving it requires reproducible, user-independent laboratory work and intelligent preselection of experiments. [...]
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2021-07-26
12:38

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2021-07-19
13:39

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2021-07-13
10:23
DBCoverage [FZJ-2021-02979] Journal Article
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Aqueous ionic liquids redistribute local enzyme stability via long-range perturbation pathways
Ionic liquids (IL) and aqueous ionic liquids (aIL) are attractive (co-)solvents for biocatalysis due to their unique properties. On the other hand, the incubation of enzymes in IL or aIL often reduces enzyme activity. [...]
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2021-07-08
11:32

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2021-07-07
12:04

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2021-07-07
11:08
[FZJ-2021-02897] Journal Article
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Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms
BACKGROUND:Reduced activation of dopamine D1receptor signaling may be implicated in reward functioning as apotential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highlyexpressed in the striatum, modulates both dopamine D2- and D1-dependent signaling.METHODS:We assessed whether augmentation of D1signaling by the PDE10 inhibitor RG7203 enhances imagingand behavioral markers of reward functions in patients with schizophrenia and negative symptoms. [...]
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2021-07-07
10:00

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2021-07-06
15:26
DBCoverage [FZJ-2021-02880] Journal Article
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Prediction of response to repetitive transcranial magnetic stimulation in phantom sounds based on individual brain anatomy
Noninvasive brain stimulation can reduce severity of tinnitus phantom sounds beyond time of stimulation by inducing regional neuroplastic changes. However, there are no good clinical predictors for treatment outcome. [...]
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2021-07-06
12:49
[FZJ-2021-02878] Journal Article
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Acute or chronic pulmonary emphysema? Or both?—A contribution to the diagnosis of death due to violent asphyxiation in cases with pre-existing chronic emphysema
The diagnosis of death due to violent asphyxiation may be challenging if external injuries are missing, and a typical acute emphysema (AE) "disappears" in pre-existing chronic emphysema (CE). Eighty-four autopsy cases were systematically investigated to identify a (histo-) morphological or immunohistochemical marker combination that enables the diagnosis of violent asphyxiation in cases with a pre-existing CE ("AE in CE"). [...]

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