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2021-06-18
09:28

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2021-06-18
09:02
[FZJ-2021-02653] Journal Article
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Context aware benchmarking and tuning of a TByte-scale air quality database and web service
We present context-aware benchmarking and performance engineering of a mature TByte-scale air quality database system which was created by the Tropospheric Ozone Assessment Report (TOAR) and contains one of the world’s largest collections of near-surface air quality measurements. A special feature of our data service https://join.fz-juelich.de is on-demand processing of several air quality metrics directly from the TOAR database. [...]

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2021-06-16
09:55
[FZJ-2021-02628] Journal Article
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The many facets of bile acids in the physiology and pathophysiology of the human liver
Biological chemistry NA(0), 000010151520210156 () [10.1515/hsz-2021-0156]
Bile acids perform vital functions in the human liver and are the essential component of bile. It is therefore not surprising that the biology of bile acids is extremely complex, regulated on different levels, and involves soluble and membrane receptors as well as transporters. [...]
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2021-06-16
09:50
[FZJ-2021-02626] Journal Article
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Evidence for a credit-card-swipe mechanism in the human PC floppase ABCB4
Structure NA, S0969212621001714 () [10.1016/j.str.2021.05.013]
ABCB4 is described as an ATP-binding cassette (ABC) transporter that primarily transports lipids of the phosphatidylcholine (PC) family but is also capable of translocating a subset of typical multidrug-resistance-associated drugs. The high degree of amino acid identity of 76% for ABCB4 and ABCB1, which is a prototype multidrug-resistance-mediating protein, results in ABCB4's second subset of substrates, which overlap with ABCB1's substrates. [...]
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2021-06-16
09:44
[FZJ-2021-02624] Journal Article
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Glutamine synthetase as a central element in hepatic glutamine and ammonia metabolism: novel aspects
Biological chemistry NA, 000010151520210166 () [10.1515/hsz-2021-0166]
Glutamine synthetase (GS) in the liver is expressed in a small perivenous, highly specializedhepatocyte population and is essential for the maintenance of low, non‐toxic ammonia levelsin the organism. However, GS activity can be impaired by tyrosine nitration of the enzyme inresponse to oxidative/nitrosative stress in a pH‐sensitive way. [...]
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2021-06-16
09:37
[FZJ-2021-02621] Journal Article
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Liver cell hydration and integrin signaling
Biological chemistry NA, 000010151520210193 () [10.1515/hsz-2021-0193]
Liver cell hydration (cell volume) is dynamic and can change within minutes under theinfluence of hormones, nutrients, and oxidative stress. Such volume changes were identified asa novel and important modulator of cell function. [...]
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2021-06-14
09:55
[FZJ-2021-02603] Journal Article
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The Crucial Role of Water in the Stability and Electrocatalytic Activity of Pt Electrodes
Understanding the role of water in the activity and stability of electrocatalysts is of great interest for different fundamental reactions. Investigations aiming to expand understanding of this are very challenging in aqueous electrolytes. [...]
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2021-06-10
14:12

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2021-06-09
09:22

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2021-06-08
13:58
DBCoverage [FZJ-2021-02547] Journal Article
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Trends in the hyperfine interactions of magnetic adatoms on thin insulating layers
Nuclear spins are among the potential candidates prospected for quantum information technology. A recent breakthrough enabled to atomically resolve their interaction with the electron spin, the so-called hyperfine interaction, within individual atoms utilizing scanning tunneling microscopy (STM). [...]

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