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001002038 1001_ $$0P:(DE-Juel1)176527$$aSchaffrath, Anja$$b0
001002038 245__ $$aPatients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
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001002038 520__ $$aMisfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used surface-based fluorescence intensity distribution analysis (sFIDA) to detect and quantify single particles of α-synuclein aggregates in stool of 94 PD patients, 72 isolated rapid eye movement sleep behavior disorder (iRBD) patients, and 51 healthy controls. We measured significantly elevated concentrations of α-synuclein aggregates in stool of iRBD patients versus those of controls (p = 0.024) or PD patients (p < 0.001). Our results show that α-synuclein aggregates are excreted in stool and can be measured using the sFIDA assay, which could support the diagnosis of prodromal synucleinopathies.
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001002038 7001_ $$0P:(DE-HGF)0$$aSchleyken, Sophia$$b1
001002038 7001_ $$0P:(DE-Juel1)184882$$aSeger, Aline$$b2$$ufzj
001002038 7001_ $$0P:(DE-HGF)0$$aJergas, Hannah$$b3
001002038 7001_ $$0P:(DE-Juel1)187484$$aÖzdüzenciler, Pelin$$b4$$ufzj
001002038 7001_ $$0P:(DE-Juel1)171619$$aPils, Marlene$$b5$$ufzj
001002038 7001_ $$0P:(DE-Juel1)177730$$aBlömeke, Lara$$b6
001002038 7001_ $$0P:(DE-Juel1)139572$$aCousin, Anneliese$$b7$$ufzj
001002038 7001_ $$0P:(DE-Juel1)159192$$aWillbold, Johannes$$b8
001002038 7001_ $$0P:(DE-Juel1)162212$$aBujnicki, Tuyen$$b9$$ufzj
001002038 7001_ $$0P:(DE-Juel1)157832$$aBannach, Oliver$$b10$$ufzj
001002038 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b11$$ufzj
001002038 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b12
001002038 7001_ $$0P:(DE-Juel1)179044$$aSommerauer, Michael$$b13$$ufzj
001002038 7001_ $$0P:(DE-Juel1)131613$$aBarbe, Michael T.$$b14
001002038 7001_ $$0P:(DE-Juel1)177986$$aTamgüney, Gültekin$$b15$$eCorresponding author
001002038 773__ $$0PERI:(DE-600)2819218-7$$a10.1038/s41531-023-00458-4$$gVol. 9, no. 1, p. 14$$n1$$p14$$tnpj Parkinson's Disease$$v9$$x2373-8057$$y2023
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