Journal Article

FZJ-2023-01236

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool

Schaffrath, A.FZJ* ; Schleyken, S. ; Seger, A.FZJ* ; Jergas, H. ; Özdüzenciler, P.FZJ* ; Pils, M.FZJ* ; Blömeke, L.FZJ* ; Cousin, A.FZJ* ; Willbold, J. ; Bujnicki, T.FZJ* ; Bannach, O.FZJ* ; Fink, G. R.FZJ* ; Willbold, D.FZJ* ; Sommerauer, M.FZJ* ; Barbe, M. T. ; Tamgüney, G. (Corresponding author)FZJ*

2023
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/33955  doi:10.1038/s41531-023-00458-4

Abstract: Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used surface-based fluorescence intensity distribution analysis (sFIDA) to detect and quantify single particles of α-synuclein aggregates in stool of 94 PD patients, 72 isolated rapid eye movement sleep behavior disorder (iRBD) patients, and 51 healthy controls. We measured significantly elevated concentrations of α-synuclein aggregates in stool of iRBD patients versus those of controls (p = 0.024) or PD patients (p < 0.001). Our results show that α-synuclein aggregates are excreted in stool and can be measured using the sFIDA assay, which could support the diagnosis of prodromal synucleinopathies.

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Contributing Institute(s):

1. Strukturbiochemie (IBI-7)
2. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5244 - Information Processing in Neuronal Networks (POF4-524) (POF4-524)
2. DFG project 431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029) (431549029)

Appears in the scientific report 2023

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