% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schaffrath:1002038,
      author       = {Schaffrath, Anja and Schleyken, Sophia and Seger, Aline and
                      Jergas, Hannah and Özdüzenciler, Pelin and Pils, Marlene
                      and Blömeke, Lara and Cousin, Anneliese and Willbold,
                      Johannes and Bujnicki, Tuyen and Bannach, Oliver and Fink,
                      Gereon R. and Willbold, Dieter and Sommerauer, Michael and
                      Barbe, Michael T. and Tamgüney, Gültekin},
      title        = {{P}atients with isolated {REM}-sleep behavior disorder have
                      elevated levels of alpha-synuclein aggregates in stool},
      journal      = {npj Parkinson's Disease},
      volume       = {9},
      number       = {1},
      issn         = {2373-8057},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {FZJ-2023-01236},
      pages        = {14},
      year         = {2023},
      abstract     = {Misfolded and aggregated α-synuclein is a
                      neuropathological hallmark of Parkinson’s disease (PD).
                      Thus, α-synuclein aggregates are regarded as a biomarker
                      for the development of diagnostic assays. Quantification of
                      α-synuclein aggregates in body fluids is challenging, and
                      requires highly sensitive and specific assays. Recent
                      studies suggest that α-synuclein aggregates may be shed
                      into stool. We used surface-based fluorescence intensity
                      distribution analysis (sFIDA) to detect and quantify single
                      particles of α-synuclein aggregates in stool of 94 PD
                      patients, 72 isolated rapid eye movement sleep behavior
                      disorder (iRBD) patients, and 51 healthy controls. We
                      measured significantly elevated concentrations of
                      α-synuclein aggregates in stool of iRBD patients versus
                      those of controls (p = 0.024) or PD patients (p < 0.001).
                      Our results show that α-synuclein aggregates are excreted
                      in stool and can be measured using the sFIDA assay, which
                      could support the diagnosis of prodromal synucleinopathies.},
      cin          = {IBI-7 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524) / DFG project 431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5244 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36732520},
      UT           = {WOS:001002245600001},
      doi          = {10.1038/s41531-023-00458-4},
      url          = {https://juser.fz-juelich.de/record/1002038},
}