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001005145 1001_ $$0P:(DE-Juel1)171348$$aFigueroa Miranda, Gabriela$$b0
001005145 245__ $$aDelineating charge and capacitance transduction in system-integrated graphene-based BioFETs used as aptasensors for malaria detection
001005145 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2022
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001005145 520__ $$aDespite significant eradication efforts, malaria remains a persistent infectious disease with high mortality due to the lack of efficient point-of-care (PoC) screening solutions required to manage low-density asymptomatic parasitemia. In response, we demonstrate a quantitative electrical biosensor based on system-integrated two-dimensional field-effect transistors (2DBioFETs) of reduced graphene oxide (rGO) as transducer for high sensitivity screening of the main malaria biomarker, Plasmodium falciparum lactate dehydrogenase (PfLDH). The 2DBioFETs were biofunctionalized with pyrene-modified 2008s aptamers as specific PfLDH receptors. While we systematically optimize biosensor interface for optimal performance, aptamer-protein transduction at 2DBioFETs is elucidated based on delineation of charge and capacitance in an updated analytical model for two-dimensional rGO/biofunctional layer/electrolyte (2DiBLE) interfaces. Our 2DBioFET-aptasensors display a limit-of-detection down to 0.78 fM (0.11 pg/mL), dynamic ranges over 9 orders of magnitude (subfemto to submicromolar), high sensitivity, and selectivity in human serum validating their diagnostic potential as rapid PoC tests for malarial management.
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001005145 7001_ $$0P:(DE-Juel1)168271$$aLiang, Yuanying$$b1
001005145 7001_ $$0P:(DE-HGF)0$$aSuranglikar, Mohit$$b2
001005145 7001_ $$0P:(DE-HGF)0$$aStadler, Matthias$$b3
001005145 7001_ $$0P:(DE-HGF)0$$aSamane, Nagesh$$b4
001005145 7001_ $$0P:(DE-HGF)0$$aTintelott, Marcel$$b5
001005145 7001_ $$0P:(DE-HGF)0$$aLo, Young$$b6
001005145 7001_ $$0P:(DE-HGF)0$$aTanner, Julian A.$$b7
001005145 7001_ $$0P:(DE-Juel1)191090$$aVu, Duy Tam$$b8
001005145 7001_ $$0P:(DE-HGF)0$$aKnoch, Joachim$$b9
001005145 7001_ $$0P:(DE-HGF)0$$aIngebrandt, Sven$$b10
001005145 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b11
001005145 7001_ $$0P:(DE-HGF)0$$aPachauri, Vivek$$b12
001005145 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b13$$eCorresponding author
001005145 773__ $$0PERI:(DE-600)1496379-6$$a10.1016/j.bios.2022.114219$$p114219$$tBiosensors and bioelectronics$$v208$$x0956-5663$$y2022
001005145 8564_ $$uhttps://juser.fz-juelich.de/record/1005145/files/rGOISFET_malarial%20parasitemia_main.pdf$$yPublished on 2022-03-26. Available in OpenAccess from 2024-03-26.
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