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@ARTICLE{FigueroaMiranda:1005145,
      author       = {Figueroa Miranda, Gabriela and Liang, Yuanying and
                      Suranglikar, Mohit and Stadler, Matthias and Samane, Nagesh
                      and Tintelott, Marcel and Lo, Young and Tanner, Julian A.
                      and Vu, Duy Tam and Knoch, Joachim and Ingebrandt, Sven and
                      Offenhäusser, Andreas and Pachauri, Vivek and Mayer, Dirk},
      title        = {{D}elineating charge and capacitance transduction in
                      system-integrated graphene-based {B}io{FET}s used as
                      aptasensors for malaria detection},
      journal      = {Biosensors and bioelectronics},
      volume       = {208},
      issn         = {0956-5663},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2023-01333},
      pages        = {114219},
      year         = {2022},
      abstract     = {Despite significant eradication efforts, malaria remains a
                      persistent infectious disease with high mortality due to the
                      lack of efficient point-of-care (PoC) screening solutions
                      required to manage low-density asymptomatic parasitemia. In
                      response, we demonstrate a quantitative electrical biosensor
                      based on system-integrated two-dimensional field-effect
                      transistors (2DBioFETs) of reduced graphene oxide (rGO) as
                      transducer for high sensitivity screening of the main
                      malaria biomarker, Plasmodium falciparum lactate
                      dehydrogenase (PfLDH). The 2DBioFETs were biofunctionalized
                      with pyrene-modified 2008s aptamers as specific PfLDH
                      receptors. While we systematically optimize biosensor
                      interface for optimal performance, aptamer-protein
                      transduction at 2DBioFETs is elucidated based on delineation
                      of charge and capacitance in an updated analytical model for
                      two-dimensional rGO/biofunctional layer/electrolyte (2DiBLE)
                      interfaces. Our 2DBioFET-aptasensors display a
                      limit-of-detection down to 0.78 fM (0.11 pg/mL), dynamic
                      ranges over 9 orders of magnitude (subfemto to
                      submicromolar), high sensitivity, and selectivity in human
                      serum validating their diagnostic potential as rapid PoC
                      tests for malarial management.},
      cin          = {IBI-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35367704},
      UT           = {WOS:000792492900006},
      doi          = {10.1016/j.bios.2022.114219},
      url          = {https://juser.fz-juelich.de/record/1005145},
}