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| Hauptseite > Publikationsdatenbank > Delineating charge and capacitance transduction in system-integrated graphene-based BioFETs used as aptasensors for malaria detection > print |
| Hauptseite > Publikationsdatenbank > Delineating charge and capacitance transduction in system-integrated graphene-based BioFETs used as aptasensors for malaria detection > print |
| 001 | 1005145 | ||
| 005 | 20240226075353.0 | ||
| 024 | 7 | _ | |2 doi |a 10.1016/j.bios.2022.114219 |
| 024 | 7 | _ | |2 Handle |a 2128/34137 |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |0 P:(DE-Juel1)171348 |a Figueroa Miranda, Gabriela |b 0 |
| 245 | _ | _ | |a Delineating charge and capacitance transduction in system-integrated graphene-based BioFETs used as aptasensors for malaria detection |
| 260 | _ | _ | |a Amsterdam [u.a.] |b Elsevier Science |c 2022 |
| 336 | 7 | _ | |2 DRIVER |a article |
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| 520 | _ | _ | |a Despite significant eradication efforts, malaria remains a persistent infectious disease with high mortality due to the lack of efficient point-of-care (PoC) screening solutions required to manage low-density asymptomatic parasitemia. In response, we demonstrate a quantitative electrical biosensor based on system-integrated two-dimensional field-effect transistors (2DBioFETs) of reduced graphene oxide (rGO) as transducer for high sensitivity screening of the main malaria biomarker, Plasmodium falciparum lactate dehydrogenase (PfLDH). The 2DBioFETs were biofunctionalized with pyrene-modified 2008s aptamers as specific PfLDH receptors. While we systematically optimize biosensor interface for optimal performance, aptamer-protein transduction at 2DBioFETs is elucidated based on delineation of charge and capacitance in an updated analytical model for two-dimensional rGO/biofunctional layer/electrolyte (2DiBLE) interfaces. Our 2DBioFET-aptasensors display a limit-of-detection down to 0.78 fM (0.11 pg/mL), dynamic ranges over 9 orders of magnitude (subfemto to submicromolar), high sensitivity, and selectivity in human serum validating their diagnostic potential as rapid PoC tests for malarial management. |
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| 700 | 1 | _ | |0 P:(DE-Juel1)168271 |a Liang, Yuanying |b 1 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Suranglikar, Mohit |b 2 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Stadler, Matthias |b 3 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Samane, Nagesh |b 4 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Tintelott, Marcel |b 5 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Lo, Young |b 6 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Tanner, Julian A. |b 7 |
| 700 | 1 | _ | |0 P:(DE-Juel1)191090 |a Vu, Duy Tam |b 8 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Knoch, Joachim |b 9 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Ingebrandt, Sven |b 10 |
| 700 | 1 | _ | |0 P:(DE-Juel1)128713 |a Offenhäusser, Andreas |b 11 |
| 700 | 1 | _ | |0 P:(DE-HGF)0 |a Pachauri, Vivek |b 12 |
| 700 | 1 | _ | |0 P:(DE-Juel1)128707 |a Mayer, Dirk |b 13 |e Corresponding author |
| 773 | _ | _ | |0 PERI:(DE-600)1496379-6 |a 10.1016/j.bios.2022.114219 |p 114219 |t Biosensors and bioelectronics |v 208 |x 0956-5663 |y 2022 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1005145/files/rGOISFET_malarial%20parasitemia_main.pdf |y Published on 2022-03-26. Available in OpenAccess from 2024-03-26. |
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