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001005147 1001_ $$0P:(DE-HGF)0$$aWeiß, Lennart JK$$b0
001005147 245__ $$aPrototype Digital Lateral Flow Sensor Using Impact Electrochemistry in a Competitive Binding Assay
001005147 260__ $$aWashington, DC$$bACS Publications$$c2022
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001005147 520__ $$aThis work demonstrates a lateral flow assay concept on the basis of stochastic-impact electrochemistry. To this end, we first elucidate requirements to employ silver nanoparticles as redox-active labels. Then, we present a prototype that utilizes nanoimpacts from biotinylated silver nanoparticles as readouts to detect free biotin in solution based on competitive binding. The detection is performed in a membrane-based microfluidic system, where free biotin and biotinylated particles compete for streptavidin immobilized on embedded latex beads. Excess nanoparticles are then registered downstream at an array of detection electrodes. In this way, we establish a proof of concept that serves as a blueprint for future “digital” lateral flow sensors.
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001005147 7001_ $$0P:(DE-Juel1)140264$$aRinklin, Philipp$$b1
001005147 7001_ $$0P:(DE-HGF)0$$aThakur, Bhawana$$b2
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001005147 7001_ $$0P:(DE-HGF)0$$aUrl, Heike$$b4
001005147 7001_ $$0P:(DE-HGF)0$$aKopic, Inola$$b5
001005147 7001_ $$0P:(DE-HGF)0$$aHoven, Darius$$b6
001005147 7001_ $$0P:(DE-HGF)0$$aBanzet, Marko$$b7
001005147 7001_ $$0P:(DE-HGF)0$$avon Trotha, Tassilo$$b8
001005147 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b9$$eCorresponding author
001005147 7001_ $$0P:(DE-Juel1)128745$$aWolfrum, Bernhard$$b10
001005147 773__ $$0PERI:(DE-600)2843497-3$$a10.1021/acssensors.2c00728$$n7$$p1967-1976$$tACS sensors$$v7$$x2379-3694$$y2022
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