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@ARTICLE{Wei:1005147,
author = {Weiß, Lennart JK and Rinklin, Philipp and Thakur, Bhawana
and Music, Emir and Url, Heike and Kopic, Inola and Hoven,
Darius and Banzet, Marko and von Trotha, Tassilo and Mayer,
Dirk and Wolfrum, Bernhard},
title = {{P}rototype {D}igital {L}ateral {F}low {S}ensor {U}sing
{I}mpact {E}lectrochemistry in a {C}ompetitive {B}inding
{A}ssay},
journal = {ACS sensors},
volume = {7},
number = {7},
issn = {2379-3694},
address = {Washington, DC},
publisher = {ACS Publications},
reportid = {FZJ-2023-01335},
pages = {1967-1976},
year = {2022},
abstract = {This work demonstrates a lateral flow assay concept on the
basis of stochastic-impact electrochemistry. To this end, we
first elucidate requirements to employ silver nanoparticles
as redox-active labels. Then, we present a prototype that
utilizes nanoimpacts from biotinylated silver nanoparticles
as readouts to detect free biotin in solution based on
competitive binding. The detection is performed in a
membrane-based microfluidic system, where free biotin and
biotinylated particles compete for streptavidin immobilized
on embedded latex beads. Excess nanoparticles are then
registered downstream at an array of detection electrodes.
In this way, we establish a proof of concept that serves as
a blueprint for future “digital” lateral flow sensors.},
cin = {IBI-3},
ddc = {570},
cid = {I:(DE-Juel1)IBI-3-20200312},
pnm = {5241 - Molecular Information Processing in Cellular Systems
(POF4-524)},
pid = {G:(DE-HGF)POF4-5241},
typ = {PUB:(DE-HGF)16},
pubmed = {35801574},
UT = {WOS:000828468100001},
doi = {10.1021/acssensors.2c00728},
url = {https://juser.fz-juelich.de/record/1005147},
}