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001005757 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-01611
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001005757 1001_ $$00000-0001-8166-5132$$aSvačina, Martin K. R.$$b0
001005757 245__ $$aThe gut microbiome in intravenous immunoglobulin‐treated chronic inflammatory demyelinating polyneuropathy
001005757 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2023
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001005757 520__ $$aAbstractBackground and purpose: The gut microbiome is involved in autoimmunity. Data on its composition in chronic inflammatory demyelinating polyneuropathy (CIDP), the most common chronic autoimmune disorder of peripheral nerves, are currently lacking.Methods: In this monocentric exploratory pilot study, stool samples were prospectively collected from 16 CIDP patients (mean age 58 ± 10 years, 25% female) before and 1 week after administration of intravenous immunoglobulin (IVIg). Gut microbiota were analyzed via bacterial 16S rRNA gene sequencing and compared to 15 age-matched healthy subjects (mean age 59 ± 15 years, 66% female).Results: The gut microbiota of CIDP patients showed an increased alpha-diversity (p = 0.005) and enrichment of Firmicutes, such as Blautia (p = 0.0004), Eubacterium hallii (p = 0.0004), or Ruminococcus torques (p = 0.03), and of Actinobacteriota (p = 0.03) compared to healthy subjects. IVIg administration did not alter the gut microbiome composition in CIDP in this short-term observation (p = 0.95).Conclusions: The gut microbiome in IVIg-treated CIDP shows distinct features, with increased bacterial diversity and enrichment of short-chain fatty acid producing Firmicutes. IVIg had no short-term impact on the gut microbiome in CIDP patients. As the main limitation of this exploratory pilot study was small cohort size, future studies also including therapy-naïve patients are warranted to verify our findings and to explore the impact of long-term IVIg treatment on the gut microbiome in CIDP.Keywords: autoimmunity; firmicutes; immune neuropathies; intestinal barrier; short-chain fatty acids (SCFA).
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001005757 7001_ $$0P:(DE-HGF)0$$aSprenger-Svačina, Alina$$b1
001005757 7001_ $$0P:(DE-HGF)0$$aTsakmaklis, Anastasia$$b2
001005757 7001_ $$0P:(DE-HGF)0$$aRüb, Alina M.$$b3
001005757 7001_ $$0P:(DE-HGF)0$$aKlein, Ines$$b4
001005757 7001_ $$0P:(DE-HGF)0$$aWüstenberg, Hauke$$b5
001005757 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b6$$ufzj
001005757 7001_ $$00000-0001-6205-2293$$aLehmann, Helmar C.$$b7$$eCorresponding author
001005757 7001_ $$0P:(DE-HGF)0$$aVehreschild, Maria J. G. T.$$b8
001005757 7001_ $$0P:(DE-HGF)0$$aFarowski, Fedja$$b9
001005757 773__ $$0PERI:(DE-600)2020241-6$$a10.1111/ene.15679$$gp. ene.15679$$n11$$p3551-3556$$tEuropean journal of neurology$$v30$$x1351-5101$$y2023
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