Journal Article

FZJ-2023-01611

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The gut microbiome in intravenous immunoglobulin‐treated chronic inflammatory demyelinating polyneuropathy

Svačina, M. K. R. ; Sprenger-Svačina, A. ; Tsakmaklis, A. ; Rüb, A. M. ; Klein, I. ; Wüstenberg, H. ; Fink, G. R.FZJ* ; Lehmann, H. C. (Corresponding author) ; Vehreschild, M. J. G. T. ; Farowski, F.

2023
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/ene.15679  doi:10.34734/FZJ-2023-01611

Abstract: AbstractBackground and purpose: The gut microbiome is involved in autoimmunity. Data on its composition in chronic inflammatory demyelinating polyneuropathy (CIDP), the most common chronic autoimmune disorder of peripheral nerves, are currently lacking.Methods: In this monocentric exploratory pilot study, stool samples were prospectively collected from 16 CIDP patients (mean age 58 ± 10 years, 25% female) before and 1 week after administration of intravenous immunoglobulin (IVIg). Gut microbiota were analyzed via bacterial 16S rRNA gene sequencing and compared to 15 age-matched healthy subjects (mean age 59 ± 15 years, 66% female).Results: The gut microbiota of CIDP patients showed an increased alpha-diversity (p = 0.005) and enrichment of Firmicutes, such as Blautia (p = 0.0004), Eubacterium hallii (p = 0.0004), or Ruminococcus torques (p = 0.03), and of Actinobacteriota (p = 0.03) compared to healthy subjects. IVIg administration did not alter the gut microbiome composition in CIDP in this short-term observation (p = 0.95).Conclusions: The gut microbiome in IVIg-treated CIDP shows distinct features, with increased bacterial diversity and enrichment of short-chain fatty acid producing Firmicutes. IVIg had no short-term impact on the gut microbiome in CIDP patients. As the main limitation of this exploratory pilot study was small cohort size, future studies also including therapy-naïve patients are warranted to verify our findings and to explore the impact of long-term IVIg treatment on the gut microbiome in CIDP.Keywords: autoimmunity; firmicutes; immune neuropathies; intestinal barrier; short-chain fatty acids (SCFA).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2023

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