%0 Journal Article
%A Kuzkina, Anastasia
%A Panzer, Celine
%A Seger, Aline
%A Schmitt, Daniela
%A Rößle, Jonas
%A Schreglmann, Sebastian R.
%A Knacke, Henrike
%A Salabasidou, Elena
%A Kohl, Antonia
%A Sittig, Elisabeth
%A Barbe, Michael
%A Berg, Daniela
%A Volkmann, Jens
%A Sommer, Claudia
%A Oertel, Wolfgang H.
%A Schaeffer, Eva
%A Sommerauer, Michael
%A Janzen, Annette
%A Doppler, Kathrin
%T Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy
%J Movement disorders
%V 38
%N 6
%@ 0885-3185
%C New York, NY
%I Wiley
%M FZJ-2023-01616
%P mds.29340
%D 2023
%X ABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as anα-synucleinopathy.Methods:Skin  biopsies  of  patients  with  iRBD,Parkinson’s disease (PD), and controls were analyzedusing RT-QuIC and immunohistochemical detection ofphospho-α-synuclein.Results:α-Synuclein aggregation was detected in97.4% of iRBD patients (78.4% of iRBD biopsies),87.2% of PD patients (70% of PD biopsies), and 13%of controls (7.9% of control biopsies), with a higherseeding activity in iRBD compared to PD. RT-QuICwas  more  sensitive  but  less  specific  thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a sensitive methodto detectα-synuclein aggregation in iRBD, and highseeding activity may indicate a strong involvement ofdermal nervefibers in these patients. © 2023 TheAuthors.Movement   Disorderspublished by WileyPeriodicals LLC on behalf of International Parkinsonand Movement Disorder Society.Key Words:rapid eye movement sleep behavior dis-order;α-synuclein;  Parkinson’s  disease;  real-timequaking-induced conversion; skin biopsy
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36750755
%U <Go to ISI:>//WOS:000930736600001
%R 10.1002/mds.29340
%U https://juser.fz-juelich.de/record/1005762