Journal Article

FZJ-2023-01616

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dermal Real‐Time Quaking‐Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α‐Synucleinopathy

Kuzkina, A. (First author) ; Panzer, C. ; Seger, A.FZJ* ; Schmitt, D. ; Rößle, J. ; Schreglmann, S. R. ; Knacke, H. ; Salabasidou, E. ; Kohl, A. ; Sittig, E. ; Barbe, M. ; Berg, D. ; Volkmann, J. ; Sommer, C. ; Oertel, W. H. ; Schaeffer, E. ; Sommerauer, M.FZJ* ; Janzen, A. ; Doppler, K. (Corresponding author)

2023
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.29340  doi:10.34734/FZJ-2023-01616

Abstract: ABSTRACT:Background:Skin biopsy is apotential tool for the premortem confirmation of anα-synucleinopathy.Objective:The aim was to assess the aggregationassay real-time quaking-induced conversion (RT-QuIC)of skin biopsy lysates to confirm isolated rapid eyemovement sleep behavior disorder (iRBD) as anα-synucleinopathy.Methods:Skin biopsies of patients with iRBD,Parkinson’s disease (PD), and controls were analyzedusing RT-QuIC and immunohistochemical detection ofphospho-α-synuclein.Results:α-Synuclein aggregation was detected in97.4% of iRBD patients (78.4% of iRBD biopsies),87.2% of PD patients (70% of PD biopsies), and 13%of controls (7.9% of control biopsies), with a higherseeding activity in iRBD compared to PD. RT-QuICwas more sensitive but less specific thanimmunohistochemistry.Conclusions:Dermal RT-QuIC is a sensitive methodto detectα-synuclein aggregation in iRBD, and highseeding activity may indicate a strong involvement ofdermal nervefibers in these patients. © 2023 TheAuthors.Movement Disorderspublished by WileyPeriodicals LLC on behalf of International Parkinsonand Movement Disorder Society.Key Words:rapid eye movement sleep behavior dis-order;α-synuclein; Parkinson’s disease; real-timequaking-induced conversion; skin biopsy

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 5252 - Brain Dysfunction and Plasticity (POF4-525) (POF4-525)
2. DFG project 491111487 - Open-Access-Publikationskosten / 2022 - 2024 / Forschungszentrum Jülich (OAPKFZJ) (491111487) (491111487)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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